Results 1 to 10 of about 71,418 (189)

P2-Pyrimidinergic Receptors and Their Ligands

Current Pharmaceutical Design, 2002
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14).
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P2 receptors in the murine gastrointestinal tract

Neuropharmacology, 2002
The actions of adenosine, adenosine 5'-triphosphate (ATP), 2-methylthio adenosine diphosphate ADP (2-MeSADP), 2-methylthio ATP (2-MeSATP), alpha,beta-methylene ATP (alpha,beta-meATP) and uridine triphosphate (UTP) on isolated segments of mouse stomach (fundus), duodenum, ileum and colon were investigated. The localization of P2Y(1), P2Y(2), P2Y(4), P2X(
GIARONI, CRISTINA, KNIGHT G. E., RUAN H. Z., GLASS R., BARDINI M., LECCHINI, SERGIO, FRIGO, GIANMARIO, BURNSTOCK G.   +7 more
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Adventures in the pharmacological analysis of P2 receptors

Journal of the Autonomic Nervous System, 2000
The pharmacological classification of P2 receptors owes its origin to the pioneering efforts of Geoff Burnstock and those who followed him, research that was conducted primarily in physiological experimental systems. Over recent years, the techniques of molecular biology have been increasingly applied in the study of P2 receptors while, at the same ...
Fagura, M.S., Jarvis, Gavin, Dougall, I.G., Leff, P.   +3 more
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Purinergic (P2) Receptors in the Kidney

2003
Publisher Summary This chapter focuses on renal P2 receptors and their relationship to the renal effects of adenosine triphosphate (ATP). It also focuses on the nonvascular P2 receptors of renal epithelia. The effects of adenosine on renal function, the distribution of its P1 (A 1–3 subtypes) receptors in kidney tissue, and the potential of this ...
Leipziger, J., Bailey, M.A., Unwin, R.J.
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Agonists and antagonists for P2 receptors.

Novartis Foundation symposium, 2006
Recent work has identified nucleotide agonists selective for P2Y1, P2Y2 and P2Y6 receptors and nucleotide antagonists selective for P2Y1, P2Y12 and P2X1 receptors. Selective non-nucleotide antagonists have been reported for P2Y1, P2Y2, P2Y6, P2Y12, P2Y13, P2X(2/3)/P2X3 and P2X7 receptors.
Pedro Besada, Bhalchandra V. Joshi, Liaman K. Mamedova, Stefano Costanzi, Andrei A. Ivanov, Hyojin Ko, Dae Hong Shin, Kenneth A. Jacobson   +7 more
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The P2 Nucleotide Receptors

1998
Part I. Historical Perspectives of P2 Nucleotide Receptors. History of Extracellular Nucleotides and Their Receptors, G. Burnstock. Part II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors. P2x Receptors: Cloned and Expressed, R. J. Evans, A. Surprenant, and R. A. North.
Gary A. Weisman, John T. Turner, Jeffrey S. Fedan   +2 more
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P2 nucleotide receptors in osteoclasts

Drug Development Research, 2001
AbstractOsteoclasts are large, multinucleated cells responsible for the resorption of bone and other mineralized tissues. Whereas low concentrations of extracellular ATP stimulate osteoclast formation and resorptive activity, high concentrations inhibit osteoclast formation.
Lin N. Naemsch, Xiaobing Du, Stephen M. Sims, S. Jeffrey Dixon   +3 more
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P2 receptors meet the immune system

Trends in Pharmacological Sciences, 2001
Abstract The 1st International Workshop on Nucleotides and their Receptors in the Immune System was held on 8–10 September 2000 at the University of Ferrara, Ferrara, Italy.
DI VIRGILIO, Francesco, BOREA, Pier Andrea, ILLES P.   +2 more
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The platelet P2 receptors in arterial thrombosis

Blood Cells, Molecules, and Diseases, 2006
ADP and ATP play a crucial role in hemostasis and thrombosis and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X1 and the two G protein-coupled P2Y1 and P2Y12 ADP receptors selectively contribute to platelet aggregation.
Béatrice Hechler, Catherine Léon, Christian Gachet   +2 more
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Salivary Gland P2 Nucleotide Receptors

Critical Reviews in Oral Biology & Medicine, 1999
The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland ...
J.T. Turner, L.A. landon, Barbara R. Talamo, Simon J. Gibbons   +3 more
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