Targeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy [PDF]
Journal of Inflammation Research, 2021 Tobias Engel,1,2,* Jonathon Smith,1,2,* Mariana Alves1 1Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland; 2FutureNeuro, Science Foundation ...
Engel T, Smith J, Alves M
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Role of Nucleotide P2 Receptors in the Immune System: Focus on Effector T Cells [PDF]
CellsThe emergence of purinergic signaling has given ATP and other extracellular nucleotides a whole new perspective. This concept refers to the fact that extracellular nucleotides released by most cells act as signaling molecules via specific membrane ...
Romuald Brice Babou Kammoe +2 more
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Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources [PDF]
Frontiers in Pharmacology, 2020 P2 receptors are a family of transmembrane receptors activated by nucleotides and nucleosides. Two classes have been described in mammals, P2X and P2Y, which are implicated in various diseases.
Anael Viana Pinto Alberto +3 more
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Purinergic P2 Receptors: Novel Mediators of Mechanotransduction [PDF]
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
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Degranulation of human mast cells: modulation by P2 receptors’ agonists [PDF]
Frontiers in Immunology, 2023 Since the late 1970s, there has been an alarming increase in the incidence of asthma and its morbidity and mortality. Acute obstruction and inflammation of allergic asthmatic airways are frequently caused by inhalation of exogenous substances such as ...
Edward S. Schulman +2 more
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P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction [PDF]
Frontiers in Pharmacology, 2020 Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel.
Mahmoud G. Khalafalla +15 more
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Altered Purinergic Signaling in Neurodevelopmental Disorders: Focus on P2 Receptors [PDF]
Biomolecules, 2023 With the umbrella term ‘neurodevelopmental disorders’ (NDDs) we refer to a plethora of congenital pathological conditions generally connected with cognitive, social behavior, and sensory/motor alterations.
Marta Boccazzi +4 more
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P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells [PDF]
Biomolecules, 2022 Extracellular ATP (eATP) and P2 receptors are novel emerging regulators of T-lymphocyte responses. Cellular ATP is released via multiple pathways and accumulates at sites of tissue damage and inflammation. P2 receptor expression and function are affected
Valentina Vultaggio-Poma +1 more
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Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors [PDF]
Virulence, 2018 Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao +10 more
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Modeling interactions among individual P2 receptors to explain complex response patterns over a wide range of ATP concentrations [PDF]
Frontiers in Physiology, 2016 EExtracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts.
Shu Xing +4 more
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