P2 receptors and platelet function. [PDF]
Purinergic Signal, 2011 Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive feedback mechanism to cause further platelet activation and amplify ...
Hechler B, Gachet C.
europepmc +6 more sources
P2 receptors in renal autoregulation. [PDF]
Curr Vasc Pharmacol, 2014 Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood.
Guan Z +3 more
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P2 Receptors and Platelet Activation [PDF]
The Scientific World Journal, 2002 Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors.
Satva P. Kunapuli
doaj +3 more sources
Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies
Journal of Pharmacological Sciences, 2022 Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been extensively studied in pain signaling.
Kazuhide Inoue
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Modeling interactions among individual P2 receptors to explain complex response patterns over a wide range of ATP concentrations [PDF]
Frontiers in Physiology, 2016 EExtracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts.
Shu Xing +4 more
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Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. [PDF]
PLoS ONE, 2016 ATP and other nucleotides are released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y ...
Anael Viana Pinto Alberto +8 more
doaj +2 more sources
Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function [PDF]
Frontiers in Immunology, 2020 Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space.
Carola Ledderose, Wolfgang G. Junger
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Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources [PDF]
Frontiers in Pharmacology, 2020 P2 receptors are a family of transmembrane receptors activated by nucleotides and nucleosides. Two classes have been described in mammals, P2X and P2Y, which are implicated in various diseases.
Anael Viana Pinto Alberto +3 more
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Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery [PDF]
Molecules, 2012 Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves +4 more
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Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]
, 1998 Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L. +13 more
core +4 more sources