Results 11 to 20 of about 56,235 (293)

Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. [PDF]

open access: yesPLoS ONE, 2016
ATP and other nucleotides are released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y ...
Anael Viana Pinto Alberto   +8 more
doaj   +2 more sources

Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources [PDF]

open access: yesFrontiers in Pharmacology, 2020
P2 receptors are a family of transmembrane receptors activated by nucleotides and nucleosides. Two classes have been described in mammals, P2X and P2Y, which are implicated in various diseases.
Anael Viana Pinto Alberto   +3 more
doaj   +2 more sources

Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery [PDF]

open access: yesMolecules, 2012
Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves   +4 more
doaj   +2 more sources

Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice [PDF]

open access: yesScientific Reports, 2018
The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness,
Chun Yang   +8 more
doaj   +2 more sources

Lipids modulate the dynamics of GPCR:β-arrestin interaction [PDF]

open access: yesNature Communications
β-arrestins are key molecular partners of G Protein-Coupled Receptors (GPCRs), triggering not only their desensitization but also intracellular signaling.
Antoniel A. S. Gomes   +8 more
doaj   +2 more sources

Physiologic roles of P2 receptors in leukocytes. [PDF]

open access: yesJ Leukoc Biol, 2022
AbstractSince their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the adaptive immune response. In particular, P2 receptors, which respond to extracellular nucleotides,
Alberto AVP   +10 more
europepmc   +3 more sources

P2 receptor subtypes in the cardiovascular system [PDF]

open access: greenBiochemical Journal, 1998
Extracellular nucleotides have been implicated in a number of physiological functions. Nucleotides act on cell-surface receptors known as P2 receptors, of which several subtypes have been cloned. Both ATP and ADP are stored in platelets and are released upon platelet activation.
Satya P. Kunapuli, James L. Daniel
openalex   +3 more sources

P2 receptors in atherosclerosis and postangioplasty restenosis [PDF]

open access: hybridPurinergic Signalling, 2006
Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components and is thought to be initiated by endothelial dysfunction [1-3]. Extracellular nucleotides that are released from a variety of arterial and blood cells [4] can bind to P2 receptors and modulate proliferation and migration of ...
Cheikh I. Seye   +5 more
openalex   +5 more sources

P2 receptors and immunity.

open access: yesMicrobes Infect, 2012
Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release ...
Rayah A   +2 more
europepmc   +5 more sources

Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?

open access: yesCells, 2021
Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi   +5 more
doaj   +1 more source

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