Results 11 to 20 of about 2,679,270 (321)
Physiologic roles of P2 receptors in leukocytes [PDF]
Journal of Leukocyte Biology, 2022 Since their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the ...
A. P. Alberto +10 more
semanticscholar +4 more sources
P2 receptors and platelet function [PDF]
Purinergic Signalling, 2011 Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive feedback mechanism to cause further platelet activation and amplify ...
Béatrice Hechler, Christian Gachet
semanticscholar +6 more sources
P2 receptors in renal autoregulation. [PDF]
Current Vascular Pharmacology, 2014 Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood.
Z. Guan +3 more
semanticscholar +4 more sources
Targeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy [PDF]
Journal of Inflammation Research, 2021 Tobias Engel,1,2,* Jonathon Smith,1,2,* Mariana Alves1 1Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland; 2FutureNeuro, Science Foundation ...
Engel T, Smith J, Alves M
doaj +3 more sources
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. [PDF]
PLoS ONE, 2016 ATP and other nucleotides are released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y ...
Anael Viana Pinto Alberto +8 more
doaj +3 more sources
Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors [PDF]
Virulence, 2018 Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao +10 more
doaj +3 more sources
Microbes and Infection, 2012 Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release ...
Amel Rayah +2 more
semanticscholar +5 more sources
Modeling interactions among individual P2 receptors to explain complex response patterns over a wide range of ATP concentrations [PDF]
Frontiers in Physiology, 2016 EExtracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts.
Shu Xing +4 more
doaj +3 more sources
Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery [PDF]
Molecules, 2012 Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves +4 more
doaj +3 more sources
Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus [PDF]
Int J Mol Sci, 2021 ATP and other nucleotides are important glio-/neurotransmitters in the central nervous system. They bind to purinergic P2X and P2Y receptors that are ubiquitously expressed in various brain regions modulating various physiological and pathophysiological ...
J. Lommen +4 more
semanticscholar +2 more sources