Results 11 to 20 of about 56,235 (293)
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. [PDF]
ATP and other nucleotides are released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y ...
Anael Viana Pinto Alberto+8 more
doaj +2 more sources
Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources [PDF]
P2 receptors are a family of transmembrane receptors activated by nucleotides and nucleosides. Two classes have been described in mammals, P2X and P2Y, which are implicated in various diseases.
Anael Viana Pinto Alberto+3 more
doaj +2 more sources
Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery [PDF]
Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves+4 more
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Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice [PDF]
The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness,
Chun Yang+8 more
doaj +2 more sources
Lipids modulate the dynamics of GPCR:β-arrestin interaction [PDF]
β-arrestins are key molecular partners of G Protein-Coupled Receptors (GPCRs), triggering not only their desensitization but also intracellular signaling.
Antoniel A. S. Gomes+8 more
doaj +2 more sources
Physiologic roles of P2 receptors in leukocytes. [PDF]
AbstractSince their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the adaptive immune response. In particular, P2 receptors, which respond to extracellular nucleotides,
Alberto AVP+10 more
europepmc +3 more sources
P2 receptor subtypes in the cardiovascular system [PDF]
Extracellular nucleotides have been implicated in a number of physiological functions. Nucleotides act on cell-surface receptors known as P2 receptors, of which several subtypes have been cloned. Both ATP and ADP are stored in platelets and are released upon platelet activation.
Satya P. Kunapuli, James L. Daniel
openalex +3 more sources
P2 receptors in atherosclerosis and postangioplasty restenosis [PDF]
Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components and is thought to be initiated by endothelial dysfunction [1-3]. Extracellular nucleotides that are released from a variety of arterial and blood cells [4] can bind to P2 receptors and modulate proliferation and migration of ...
Cheikh I. Seye+5 more
openalex +5 more sources
Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release ...
Rayah A+2 more
europepmc +5 more sources
Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?
Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi+5 more
doaj +1 more source