Results 21 to 30 of about 71,418 (189)
Multiscale analysis and simulation of a signalling process with surface diffusion [PDF]
, 2020 We present and analyze a model for cell signaling processes in biological tissues. The model includes diffusion and nonlinear reactions on the cell surfaces and both inter- and intracellular signaling.
Ptashnyk, Mariya +1 more
core +2 more sources
P2 Receptors in Renal Autoregulation [PDF]
Current Vascular Pharmacology, 2014 Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood.
Zhengrong Guan +3 more
openaire +3 more sources
Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]
, 1992 Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg +5 more
core +1 more source
P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells [PDF]
, 2004 BACKGROUND: Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson, Anders +3 more
core +2 more sources
P2 receptors in renal pathophysiology [PDF]
Purinergic Signalling, 2009 Our knowledge and understanding of the P2 receptor signalling system in the kidney have increased significantly in the last ten years. The broad range of physiological roles proposed for this receptor system and the variety of P2 receptor subtypes found in the kidney suggest that any disturbance of function may contribute to several pathological ...
James I. Elliott +3 more
openaire +2 more sources
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E. +3 more
core +2 more sources
P2 receptors in atherosclerosis and postangioplasty restenosis [PDF]
Purinergic Signalling, 2006 Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components and is thought to be initiated by endothelial dysfunction [1-3]. Extracellular nucleotides that are released from a variety of arterial and blood cells [4] can bind to P2 receptors and modulate proliferation and migration of ...
Gary A. Weisman +5 more
openaire +4 more sources
P2 receptors in cardiovascular regulation and disease [PDF]
Purinergic Signalling, 2007 The role of ATP as an extracellular signalling molecule is now well established and evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play important roles in cardiovascular physiology and pathophysiology, acting via P2X (ion channel) and P2Y (G protein-coupled) receptors.
Erlinge, D, Burnstock, G
openaire +5 more sources
A Brief View of Molecular Modeling Approaches to P2 Receptors [PDF]
, 2019 Purinergic receptors are a class of receptors distributed into two groups, P1 and P2. P1 receptors are activated by nucleosides, like adenosine, while nucleotides active P2 receptors.
Alberto, Anael V.P. +4 more
core +1 more source
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
core +1 more source