Results 31 to 40 of about 56,235 (293)
The tumor microenvironment plays a major role in the ability of the tumor cells to undergo metastasis. A major player of tumors gaining metastatic property is the inflammatory protein, cyclooxygenase 2 (COX-2).
Shilpa Sharma+2 more
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P2 receptors and chronic pain [PDF]
There is abundant evidence that extracellular ATP and other nucleotides have an important role in pain signaling at both the periphery and in the CNS. The focus of attention now is on the possibility that endogenous ATP and its receptor system might be activated in chronic pathological pain states, particularly in neuropathic and inflammatory pain ...
openaire +2 more sources
P2 receptors in renal pathophysiology [PDF]
Our knowledge and understanding of the P2 receptor signalling system in the kidney have increased significantly in the last ten years. The broad range of physiological roles proposed for this receptor system and the variety of P2 receptor subtypes found in the kidney suggest that any disturbance of function may contribute to several pathological ...
James I. Elliott+3 more
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P2 receptors in cardiovascular regulation and disease [PDF]
The role of ATP as an extracellular signalling molecule is now well established and evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play important roles in cardiovascular physiology and pathophysiology, acting via P2X (ion channel) and P2Y (G protein-coupled) receptors.
Erlinge, D, Burnstock, G
openaire +5 more sources
Emerging roles of purinergic signaling in anti-cancer therapy resistance
Cancer is a complex disease with a rapid growing incidence and often characterized by a poor prognosis. Although impressive advances have been made in cancer treatments, resistance to therapy remains a critical obstacle for the improvement of patients ...
Michele Zanoni+3 more
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5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters
5-hydroxytryptamine (5-HT) is derived from the essential amino acid L-tryptophan. Although the compound has been studied extensively for its neuronal handling and synaptic actions, serotonin 5-HT receptors can be found extra-synaptically and not only in ...
Rafael Franco+9 more
doaj +1 more source
ATP as a Multi-target Danger Signal in the Brain
ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia ...
Ricardo J Rodrigues+4 more
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Transmission to interneurons is via slow excitatory synaptic potentials mediated by P2Y(1) receptors during descending inhibition in guinea-pig ileum. [PDF]
BACKGROUND: The nature of synaptic transmission at functionally distinct synapses in intestinal reflex pathways has not been fully identified. In this study, we investigated whether transmission between interneurons in the descending inhibitory pathway ...
Peter D J Thornton+3 more
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Molecular defects of the platelet P2 receptors. [PDF]
Human platelets express three types of P2 receptors, which play important roles in platelet function: P2X(1), P2Y(1) and P2Y(12). Only patients with either quantitative or qualitative abnormalities of the platelet P2Y(12) receptor have been well-characterized so far.
Cattaneo M.
europepmc +6 more sources
Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies
Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been extensively studied in pain signaling.
Kazuhide Inoue
doaj