Results 151 to 160 of about 1,333,073 (194)

Regulation of P2X3 Receptor Structure and Function

CNS & Neurological Disorders - Drug Targets, 2012
The strong expression of ATP-gated P2X3 receptors by a subpopulation of sensory neurons indicates the important role of these membrane proteins in nociceptive signaling in health and disease, especially when the latter is accompanied by chronic pain syndromes.
Fabbretti, E, Nistri, Andrea
openaire   +4 more sources

P2X3 Receptors and Sensory Transduction

, 2008
It has been known for many years that exogenously administered adenosine 5 -triphosphate (ATP) evokes acute pain, but the physiological and pathophysiological roles of endogenous ATP in nociceptive signalling are only now becoming clear. ATP produces its effects through P2X and P2Y receptors, and the P2X3 receptor is of notable importance.
Kennedy, Charles
core   +6 more sources

Novel capsaicin (VR1) and purinergic (P2X3) receptors in Hirschsprung's intestine

Journal of Pediatric Surgery, 2001
Studies of Hirschsprung's disease (HSCR) have shown that hypertrophic nerves in aganglionic bowel are mainly of extrinsic origin and may contain sensory elements. Recent advances have shown a specific capsaicin receptor VR1 (vanilloid receptor-1), and an ATP-gated ion channel P2X(3), which are expressed by sensory neurons.This study investigated, for ...
Anand, P, Dyer, N, Ford, AP, Knowles, CH, Baecker, PA, Facer, P, Tam, PKH   +6 more
openaire   +5 more sources

P2X3 receptor gating near normal body temperature

Pflügers Archiv - European Journal of Physiology, 2007
P2X3 purinoreceptors expressed in mammalian sensory neurons are involved in nociception, mechanosensory transduction, and temperature sensation. Homomeric P2X3 receptors desensitize rapidly (
Khmyz, V., Maximyuk, O., Teslenko, V., Verkhratsky, A.; id_orcid 0000-0003-2592-9898, Krishtal, O.   +4 more
openaire   +3 more sources

Update on Novel Purinergic P2X3 and P2X2/3 Receptor Antagonists and Their Potential Therapeutic Applications [PDF]

Expert Opinion on Therapeutic Patents, 2019
Introduction: Purinergic P2X3-P2X2/3 receptors are placed in nociceptive neurons' strategic location and show unique desensitization properties; hence, they represent an attractive target for many pain-related diseases.
Aleix Martí Navia, Andrea Spinaci, Rosaria Volpini   +2 more
exaly   +2 more sources

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A role for calcineurin in the desensitization of the P2X3 receptor

NeuroReport, 1997
The sensory neurone-specific ATP-gated cation channel P2X3, when expressed in Xenopus oocytes, desensitizes rapidly. Complete removal of extracellular calcium abolishes desensitization. Pretreatment of oocytes with cyclosporin also abolishes P2X3 desensitization. When the calcineurin auto-inhibitory peptide (CaN A457-481) was injected into oocytes, the
B, King, C C, Chen, A N, Akopian, G, Burnstock, J N, Wood   +4 more
openaire   +2 more sources

P2X3 and P2X2/3 Receptor Antagonists

Pharmaceutical Patent Analyst, 2013
This review provides a concise summary of the molecular properties of the ligand-gated P2X receptors, in particular those containing the X3 subunit, as well as an overview comprising the most important patent applications on P2X3 and P2X2/3 receptor antagonists published since 2001. This review is mainly focused on small molecules with P2X3 and/or P2X2/
Hedvig, Bölcskei, Bence, Farkas
openaire   +2 more sources

P2X3 Receptor Involvement in Pain States

Molecular Neurobiology, 2007
The understanding of how pain is processed at each stage in the peripheral and central nervous system is the precondition to develop new therapies for the selective treatment of pain. In the periphery, ATP can be released from various cells as a consequence of tissue injury or visceral distension and may stimulate the local nociceptors.
Kerstin, Wirkner, Beata, Sperlagh, Peter, Illes   +2 more
openaire   +2 more sources

Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors

Biochemical Pharmacology, 2021
Chronic pain is a debilitating condition that often occurs following peripheral tissue inflammation and nerve injury. This pain, especially neuropathic pain, is a significant clinical problem because of the ineffectiveness of clinically available drugs.
Kazuhide, Inoue, Makoto, Tsuda
openaire   +2 more sources

P2X3 receptors and sensitization of autonomic reflexes

Autonomic Neuroscience, 2015
A great deal of basic and applied physiology and pharmacology in sensory and autonomic neuroscience has teased apart mechanisms that drive normal perception of mechanical, thermal and chemical signals and convey them to CNS, the distinction of fiber types and receptors and channels that mediate them, and how they may become dysfunctional or maladaptive
Anthony P, Ford, Bradley J, Undem, Lori A, Birder, David, Grundy, Wioletta, Pijacka, Julian F R, Paton   +5 more
openaire   +2 more sources