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P2X7 receptor antagonism: Implications in diabetic retinopathy
Biochemical Pharmacology, 2017Diabetic retinopathy (DR) is the most frequent complication of diabetes and one of leading causes of blindness worldwide. Early phases of DR are characterized by retinal pericyte loss mainly related to concurrent inflammatory process. Recently, an important link between P2X7 receptor (P2X7R) and inflammation has been demonstrated indicating this ...
Platania C +6 more
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P2X7 Receptor as a Therapeutic Target
2016P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular influx of Na(+) and Ca(2+) and efflux of K(+). P2X7 is expressed by a wide variety of cells and its activation mediates a large number of biological processes like inflammation, neuromodulation, cell death or cell proliferation and it has been associated to ...
DE MARCHI, Elena +3 more
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Targeting the P2X7 receptor in rheumatoid arthritis: biological rationale for P2X7 antagonism.
Clinical and experimental rheumatology, 2015This paper aims to explore the functional significance of the P2X7 receptor in preclinical models of rheumatoid arthritis.Preclinical studies in vivo were performed using the rat streptococcal cell wall (SCW) arthritis model. Ex vivo cultures of lipopolysaccharide (LPS)/benzoylbenzoyl adenosine triphosphate (BzATP)-stimulated human monocytes were ...
Iain B, McInnes +3 more
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P2X7 polymorphisms and stem cell mobilisation
Leukemia, 2018Rachel, Koldej +2 more
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