Results 101 to 110 of about 1,255,934 (217)

De-escalation of anti-platelet therapy in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a narrative review

Chinese Medical Journal, 2019
. Objective:. Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment in patients with acute coronary syndromes (ACS) and in those undergoing percutaneous coronary intervention (PCI).
Ya-Ling Han, Yuan-Yuan Ji
doaj   +1 more source

Safety of Nonsteroidal Anti‐Inflammatory Drug Use in Traumatic Brain Injury

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Use of nonsteroidal anti‐inflammatory drugs (NSAIDs) after a traumatic brain injury (TBI) is controversial due to potential worsening of an intracranial hemorrhage (ICH). This study evaluated if NSAID use within 14 days of TBI was associated with a clinically significant progression of intracranial bleed (PIB).
Jennifer Beavers, Mary Katherine Cella Shultz, Leanne Atchison, Cara Lwin, Dandan Liu, Silky Chotai, Andrew J. Medvecz, Robel Beyene, Michael C. Smith, Bradley M. Dennis, Susan Hamblin   +10 more
wiley   +1 more source

Place of Prasugrel, P2Y12 receptor antagonist, in an early invasive treatment of patients with acute coronary syndrome (according to the results of multicenter randomized controlled trial ISAR-REACT 5)

Российский кардиологический журнал, 2019
The conclusion of the Expert Council reports an agreement on the place of the P2Y12 receptor blocker prasugrel in the early invasive treatment of patients with acute coronary syndrome ACS, according to the results of the multicenter randomized controlled
S. N. Tereshchenko, M. G. Glezer, S. A. Abugov, O. V. Averkov, S. I. Antipov, A. S. Galyavich, M. Yu. Gilyarov, D. V. Duplyakov, A. A. Efremushkina, D. A. Zateyshchikov, V. V. Ivanenko, E. D. Kosmacheva, O. V. Krestyaninov, Yu. M. Lopatin, E. P. Panchenko, V. V. Ryabov, E. V. Samokhvalov, I. I. Staroverov, S. A. Ustyugov, A. V. Khripun, S. V. Shalaev, R. M. Shakhnovich, I. S. Yavelov, A. N. Yakovlev, S. S. Yakushin   +24 more
doaj   +1 more source

Association Between CYP2C19 Genotype and P2Y12 Reaction Units in Patients Receiving Clopidogrel After Acute Ischemic Stroke: A Prospective, Observational Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Recurrent stroke accounts for substantial morbidity and mortality worldwide, with up to 25% of ischemic strokes occurring in patients with prior strokes. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard for secondary prevention after minor acute ischemic stroke (AIS) or high‐risk transient ischemic attack ...
Rachael M. Stone, Annie Smith, Sonya Gunter, Andrew T. Weko, Carter Gottschalk, Cheyenne Lee, Allison Ramsey, Miah Perch Weatherspoon, Bradford B. Worrall   +8 more
wiley   +1 more source

Omega-3 fatty acid ethyl esters do not improve clopidogrel associated P2Y12 inhibition in stroke patients

Neurology International, 2015
The specific action of omega-3 fatty acid ethyl esters (OFA) in preventing cerebrovascular disease remains unknown, but research has demonstrated multiple possible mechanisms.
Ping Li, Haris Kamal, Melissa Baxter, Bijal K. Mehta   +3 more
doaj   +1 more source

Pharmacogenomics of Oral P2Y12 Receptor Blockers

Journal of Pharmacogenomics & Pharmacoproteomics, 2013
Dual antiplatelet therapy of aspirin and a P2Y12 receptor antagonist is the cornerstone of therapy for patients. Thienopyridines (ticlopidine, clopidogrel and prasugrel) are prodrugs that need cytochrome–mediated conversion to active metabolites to block P2Y12 receptors and subsequent ADP-induced platelet aggregation.
openaire   +1 more source

STEMI Antithrombotic Therapy: The Evolving Role of P2Y12 Inhibitor Pretreatment in Contemporary Practice

Reviews in Cardiovascular Medicine
The P2Y12 receptor plays a central role in platelet activation, secretion, and procoagulant activity. The CURE (clopidogrel in unstable angina to prevent recurrent events) trial, conducted in 2001, was the first to effectively demonstrate the benefit of ...
Antonella Tommasino, Vincenzo Fiorentini, Giulia Mattaroccia, Alessandra Scoccia, Emanuele Barbato   +4 more
doaj   +1 more source

ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Marco Tozzi, Emilie B. Berggreen, Rui Zhang, Anders Gudiksen, Wei Li, Mathias B. Matz, Henriette Pilegaard, Jacob B. Hansen, Ivana Novak   +8 more
wiley   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, Volume 183, Issue 20, Page 5999-6006, October 2026.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Impact of Reticulated Platelets on the Antiplatelet Effect of the Intravenous P2Y12-Receptor Inhibitor Cangrelor

, 2018
Background Reticulated platelets are associated with impaired antiplatelet response to irreversibly acting P2Y12-receptor inhibitors. However, the impact of reticluated platelets (RP) on the reversibly acting injectable P2Y12-receptor ...
Christian Valina, Nikolaus Löffelhardt, Valina, Christian Marc, Kambis Mashayekhi, Mashayekhi, Kambis, Hochholzer, Willibald, Willibald Hochholzer, Christian Stratz, Neumann, Franz-Josef, Nührenberg, Thomas G., Dietmar Trenk, Thomas Nührenberg, Miroslaw Ferenc, Franz-Josef Neumann, Löffelhardt, Nikolaus, Ferenc, Miroslaw, Trenk, Dietmar, Stratz, Christian   +17 more
core   +1 more source