Results 101 to 110 of about 26,462 (230)

Feasibility and Safety on Left Bundle Branch Area Pacing With Standard Stylet‐Driven Lead: ACHIEVE‐SYNC Multicenter Prospective Observational Cohort Study

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
In the prospective multicenter study, left bundle branch area pacing using stylet‐driven pacing leads demonstrated a high procedural success rate and showed stable lead performance during long‐term follow‐up. ABSTRACT Background Right ventricular pacing increases the risk of dyssynchrony, which raises the need for more physiological pacing strategies ...
Ga‐In Yu, So‐Ryoung Lee, Tae‐Hoon Kim, Min Soo Cho, Daehoon Kim, Hee Tae Yu, Jung‐Myung Lee, Jae‐Sun Uhm, Eue‐Keun Choi, Jun Kim, Boyoung Joung, Hui‐Nam Pak, Moon‐Hyoung Lee   +12 more
wiley   +1 more source

Morphine Analgesia Pre-PPCI Is Associated with Prothrombotic State, Reduced Spontaneous Reperfusion and Greater Infarct Size [PDF]

, 2017
Schattauer GmbH Stuttgart.The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, which
Farag, Mohamed, Gorog, Diana A, Spinthakis, Nikolaos, Srinivasan, Manivannan, Sullivan, Keith, Wellsted, David   +5 more
core   +2 more sources

P2Y12-ADP receptor antagonists: Days of future and past

World Journal of Cardiology, 2016
Antiplatelet therapy is the cornerstone of the therapeutic arsenal in coronary artery disease. Thanks to a better understanding in physiology, pharmacology and pharmacogenomics huge progress were made in the field of platelet reactivity inhibition thus allowing the expansion of percutaneous coronary intervention.
Laine, Marc, Bonello, Laurent, Paganelli, Franck   +2 more
openaire   +3 more sources

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Cangrelor — Expanding therapeutic options in patients with acute coronary syndrome

Cardiology Journal
Cangrelor is the only intravenous P2Y12 receptor antagonist. It is an adenosine triphosphate analog that selectively, directly, and reversibly binds to the platelet P2Y12 receptors exerting its antiaggregatory effect. Cangrelor is characterized by linear,
Jacek Kubica, Piotr Adamski, Sławomir Dobrzycki, Robert Gajda, Mariusz Gąsior, Marek Gierlotka, Miłosz Jaguszewski, Jacek Legutko, Maciej Lesiak, Eliano P. Navarese, Piotr Niezgoda, Małgorzata Ostrowska, Tomasz Pawłowski, Agnieszka Tycińska, Julia M. Umińska, Adam Witkowski, Robert Gil   +16 more
doaj   +1 more source

Aspirin-free antithrombotic management following coronary stenting. Myth or reality?

REC: Interventional Cardiology (English Ed.), 2019
The use of aspirin in combination with a P2Y12 receptor inhibitor, also known as dual antiplatelet therapy, is at the cornerstone of treatment for patients undergoing coronary stenting.
Davide Capodanno, Roxana Mehran, Dominick J. Angiolillo   +2 more
doaj   +1 more source

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior. [PDF]

, 2015
The principle functions of neuroinflammation are to limit tissue damage and promote tissue repair in response to pathogens or injury. While neuroinflammation has utility, pathophysiological inflammatory responses, to some extent, underlie almost all ...
Beamer, Edward, Bekő, Katinka, Gölöncsér, Flóra, Horváth, Gergely, Koványi, Bence, Otrokocsi, Lilla, Sperlágh, Beáta   +6 more
core   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Constitutive P2Y2 receptor activity regulates basal lipolysis in human adipocytes [PDF]

, 2018
White adipocytes are key regulators of metabolic homeostasis, which release stored energy as free fatty acids via lipolysis. Adipocytes possess both basal and stimulated lipolytic capacity, but limited information exists regarding the molecular ...
Ahmadian, Arruda, Ashour, Bartness, Bernstein, Bowers, Brand, Cioffi, Clapham, Corriden, Gorini, Govindan, Gray, Greenberg, Grynkiewicz, Halberg, Halls, Heckmann, Hernandez-Olmos, Hoffmann, Jacobson, Juan, Jun, Katada, Kennedy, Kim, Kim, Kotnis, Krzyzanowska, La Paglia, Lazarowski, Lee, Mamedova, Meis, Micklewright, Miyoshi, Miyoshi, Nelson, Nielsen, North, Omori, Ormond, Qiao, Rafehi, Ronti, Rosen, Rutkowski, Rydén, Shi, Sivaramakrishnan, Snyder, Stokes, Sukumar, Torres, Turner, Van Harmelen, Von Kügelgen, Wang, Wedellová, Weisberg, Xue, Yegutkin, Zhang   +62 more
core   +1 more source

Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract BACKGROUND Genetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD‐associated ABI3S209F (Abi3S212F in mouse) variant regulates cytoskeletal dynamics, but its in vivo impact on pathology is unknown. METHODS: An Abi3S212F mouse was developed and crossed with
Claire A. Butler, Min Sung Gee, Katie O'Gara, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Yueh‐Hao Lu, Nellie Kwang, Kate I. Tsourmas, Christiana Prekopa, Zechuan Shi, Heidi Yahan Liang, Sherilyn D. Collins, Zachary A. Pashkutz, Jenna A. Sanchez, Kai‐Xuan Shi, Amber D. Walker, Shuling Wang, Maigan L. A. Wong, Karina Genaro, Jonathan Neumann, Angela Gomez‐Arboledas, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Ali Mortazavi, Vivek Swarup, Grant R. MacGregor, Kim N. Green   +29 more
wiley   +1 more source