Results 121 to 130 of about 26,462 (230)

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. [PDF]

, 2018
Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved.
Brass, Lawrence F., DeHelian, Daniel, Gupta, Shuchi, Ma, Peisong, Sampietro, Sara, Stalker, Timothy J., Tang, Alan, Tutwiler, Valerie   +7 more
core   +1 more source

Advantages and limitations of clopidogrel response testing methods [PDF]

, 2012
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Njegomirović Srđana, Ostojić Miodrag, Prostran Milica, Todorović Zoran, Đukanović Nina   +4 more
core   +1 more source

Pre‐operative anaemia, red blood cell transfusion and mortality after cardiac surgery: a Netherlands Heart Registration mediation analysis

Anaesthesia, Volume 81, Issue 5, Page 646-654, May 2026.
Summary Introduction Pre‐operative anaemia is an established risk factor for mortality after cardiac surgery. The extent to which this risk is mediated by complications related to red blood cell transfusion remains uncertain, particularly across different age groups.
Elisabeth M. Groenewegen, Peter G. Noordzij, Eline Vlot, Saskia Houterman, Toni Klok, Alexander J. Spanjersberg, Maarten Ter Horst, Joost M. A. A. Van Der Maaten, Susanne Eberl, Remco R. Berendsen, R. Arthur Bouwman, Bastiaan M. Gerritse, Thierry V. Scohy, Johannes S. E. Haenen, Jan Hofland, Marieke F. Kingma, Jan Van Klarenbosch, Sander Bramer, Marcel P. J. De Korte, Nicobert E. Wietsma, Olaf L. Cremer, Lizbeth Burgos Ochoa, Thijs C. D. Rettig, on behalf of the NHR Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration   +23 more
wiley   +1 more source

Omega-3 fatty acid ethyl esters do not improve clopidogrel associated P2Y12 inhibition in stroke patients

Neurology International, 2015
The specific action of omega-3 fatty acid ethyl esters (OFA) in preventing cerebrovascular disease remains unknown, but research has demonstrated multiple possible mechanisms.
Ping Li, Haris Kamal, Melissa Baxter, Bijal K. Mehta   +3 more
doaj   +1 more source

The importance of tests applied to evaluate the effectiveness of antiplatelet therapy in patients with recurrent coronary stent thrombosis [PDF]

, 2009
Background. Stent thrombosis is potentially lethal complication with huge economic burden. The role of insufficient response to antiplatelet therapy is still unclear reason for its occurrence. Case report.
Cikota Bojana, Grdinić Aleksandra, Ilić Vesna, Magić Zvonko, Majstorović Ivana, Miljić Predrag, Obradović Slobodan, Ostojić Miodrag, Radovanović Mina, Vojvodić Danilo, Đukanović Nina   +10 more
core   +1 more source

Limited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Clopidogrel is an antiplatelet agent widely utilized in cardiology. It is a prodrug activated in the liver by the cytochrome P450 isoform CYP2C19. Variability in the CYPC2C19 gene influences the activation and efficacy of clopidogrel. This is covered in guidelines from the Clinical Pharmacogenetics Implementation Consortium, the Dutch ...
Cinzia Dello Russo, Luigi Venetucci, Abisope Akintola, Dimitri Gagliardi, Ronnie Ramlogan, Munir Pirmohamed   +5 more
wiley   +1 more source

STEMI Antithrombotic Therapy: The Evolving Role of P2Y12 Inhibitor Pretreatment in Contemporary Practice

Reviews in Cardiovascular Medicine
The P2Y12 receptor plays a central role in platelet activation, secretion, and procoagulant activity. The CURE (clopidogrel in unstable angina to prevent recurrent events) trial, conducted in 2001, was the first to effectively demonstrate the benefit of ...
Antonella Tommasino, Vincenzo Fiorentini, Giulia Mattaroccia, Alessandra Scoccia, Emanuele Barbato   +4 more
doaj   +1 more source

The Use of Dual Antiplatelet Therapy in Acute Coronary Syndrome and Percutaneous Coronary Intervention

Рациональная фармакотерапия в кардиологии, 2019
Currently, cardiovascular diseases play a leading role in the structure of morbidity. It is expected that by 2020 in developing countries cardiovascular diseases will take the leading position in the structure of mortality.
A. S. Tereshchenko, E. V. Merkulov, A. N. Samko, S. A. Abugov   +3 more
doaj   +1 more source

Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers. [PDF]

, 2019
BACKGROUND: Ticagrelor is an oral P2Y12 inhibitor that is used with aspirin to reduce the risk of ischemic events among patients with acute coronary syndromes or previous myocardial infarction.
Arnold, Susan E., Bhatt, Deepak L., Jennings, Lisa K., Lee, John S., Mays, Michael C., Pollack, Charles V., Umstead, Bret R., Weitz, Jeffrey I., Xu, Sherry   +8 more
core   +1 more source

Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Patricia Martínez‐Tazo, Marina Mejias‐Ortega, Verónica López‐López, Aysha M. Bhojwani‐Cabrera, Emma Saxton, Santiago Canals, Giles Hardingham, Antonia Gutierrez, Jose P. Lopez‐Atalaya, Silvia De Santis   +9 more
wiley   +1 more source