, 2005 ADP activates human platelets through two G-protein coupled receptors, P2Y1 and P2Y12, to induce a range of functional responses. Here we have addressed the role and mechanism of P2Y12 in modulating ADP-induced platelet shape change.
Poole, AW, Hardy, AR, Hill, DJ
core +1 more source
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT CYP2C19 genetic polymorphisms impact the antiplatelet effect of clopidogrel and associate with ischemic and bleeding risk in patients undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the association of CYP2C19 and platelet reactivity (PR) with these risks, in atrial fibrillation (AF) patients undergoing PCI ...
Diona Gjermeni +12 more
wiley +1 more source
Interactions between the endothelial mediator’s nitric oxide and prostacyclin, and platelet P2Y12 receptor blockade [PDF]
, 2019 PhD thesisAn often explored hypothesis is that in at risk patients the chances of experiencing a thrombotic event is associated with the level of P2Y12 platelet blockade.
Knowles, R
core
Mind the Gap: Model-Based Switching from Selatogrel to Maintenance Therapy with Oral P2Y12 Receptor Antagonists. [PDF]
Biomolecules, 2023 Hsin CH +5 more
europepmc +1 more source
Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros +6 more
wiley +1 more source
Pharmacogenetics of P2Y12 receptor inhibitors. [PDF]
Pharmacotherapy, 2023 Thomas CD +3 more
europepmc +1 more source
Opioids and oral P2Y12 receptor inhibitors: A drug-drug interaction. [PDF]
Cardiol J, 2022 Kubica J.
europepmc +1 more source
Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of the P2Y12 receptor antagonist selatogrel. [PDF]
Clin Transl Sci, 2022 Schilling U +6 more
europepmc +1 more source
Influence of genetic polymorphisms in P2Y12 receptor signaling pathway on antiplatelet response to clopidogrel in coronary heart disease. [PDF]
BMC Cardiovasc Disord, 2022 Zhang YJ +6 more
europepmc +1 more source
Antiplatelet Activity of Tetramethylpyrazine via Regulation of the P2Y12 Receptor Downstream Signaling Pathway. [PDF]
Evid Based Complement Alternat Med, 2022 Guan B, Gao J, Tan Y, Ma X, Shi D.
europepmc +1 more source