Results 131 to 140 of about 18,821 (231)

Impact of Chronic Kidney Disease Severity on Clinical Outcomes After Drug‐Eluting Stent Implantation: A Propensity Score–Matched Analysis

Clinical Cardiology, Volume 49, Issue 6, June 2026.
Moderate‐to‐severe CKD was associated with higher MACE and renal function deterioration after DES implantation in a propensity score‐matched cohort, supporting CKD‐based cardiorenal risk stratification and closer post‐PCI monitoring. ABSTRACT Background Chronic kidney disease (CKD) is prevalent among patients undergoing percutaneous coronary ...
Hongxu Zhu, Qi Jin
wiley   +1 more source

Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]

, 2007
Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
core  

Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y12 receptor-mediated platelet aggregation.

, 2012
Farnesyl pyrophosphate (FPP) is an intermediate in cholesterol biosynthesis, and it has also been reported to activate platelet LPA (lysophosphatidic acid) receptors.
Högberg, Carl, Abdelrahman, A, Jacobson, K A, Müller, C E, Erlinge, David, Gidlöf, Olof, Olde, Björn, Deflorian, F   +7 more
core   +1 more source

Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y12 Antagonists in a cAMP- and Calcium-Dependent Manner

, 2020
We have shown previously that platelet activity can be lowered through the simultaneous inhibition of P2Y12 receptor and activation of adenosine receptors (AR).
Boguslawa Luzak, Nina Wolska, Marcin Rozalski, Hassan Kassassir, Cezary Watala   +4 more
core   +1 more source

High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease

JCI Insight
Thrombosis and inflammation are intimately linked and synergistically contribute to the pathogenesis of numerous thromboinflammatory diseases, including sickle cell disease (SCD).
Deirdre Nolfi-Donegan, Gowtham K. Annarapu, Claudette St. Croix, Michael Calderon, Cheryl A. Hillery, Sruti Shiva   +5 more
doaj   +1 more source

Assessing Functional Recovery in Ischemic Stroke: An Observational Study of Dual vs. Single Antiplatelet Therapy in Indian Patients

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim In an aging population, stroke is a leading cause of morbidity and mortality. More than 80% of stroke cases in the elderly are ischemic strokes. Stroke is the sixth most common cause of disability globally and the second most common cause after ischemic heart disease (IHD).
Sohailuddin Mohammad, Hemaakshi Gupta, Dipinder Deep Bhat, Tirunagari Navya Sree, Anveshak, Summaiah Asim, Mohammed Faizan Ahmed, Pooja Pancholi, Younes Nabgouri, Mohammed Abdul Mateen, Nagham Al Dirani   +10 more
wiley   +1 more source

Risk of major adverse cardiovascular events in CYP2C19 LoF genotype guided clopidogrel against alternative antiplatelets for CAD patients undergoing PCI: Meta‐analysis

Clinical and Translational Science
Selection of rational antagonists of P2Y12 receptor for CAD patients who inherit CYP2C19 LoF alleles remains still conflicting. This study compared the clinical outcomes in CAD patients inheriting CYP2C19 LoF alleles undergoing PCI and treated with ...
Mohitosh Biswas, Murshadul Alam Murad, Maliheh Ershadian, Most Sumaiya Khatun Kali, Chonlaphat Sukasem   +4 more
doaj   +1 more source

Feasibility and Safety on Left Bundle Branch Area Pacing With Standard Stylet‐Driven Lead: ACHIEVE‐SYNC Multicenter Prospective Observational Cohort Study

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
In the prospective multicenter study, left bundle branch area pacing using stylet‐driven pacing leads demonstrated a high procedural success rate and showed stable lead performance during long‐term follow‐up. ABSTRACT Background Right ventricular pacing increases the risk of dyssynchrony, which raises the need for more physiological pacing strategies ...
Ga‐In Yu, So‐Ryoung Lee, Tae‐Hoon Kim, Min Soo Cho, Daehoon Kim, Hee Tae Yu, Jung‐Myung Lee, Jae‐Sun Uhm, Eue‐Keun Choi, Jun Kim, Boyoung Joung, Hui‐Nam Pak, Moon‐Hyoung Lee   +12 more
wiley   +1 more source

Off-Target Effects of P2Y12 Receptor Inhibitors: Focus on Early Myocardial Fibrosis Modulation. [PDF]

Int J Mol Sci, 2023
Lofrumento F, Irrera N, Licordari R, Perfetti S, Nasso E, Liotta P, Isgrò G, Garcia-Ruiz V, Squadrito F, Carerj S, Di Bella G, Micari A, Costa F.   +12 more
europepmc   +1 more source

Fractional flow reserve versus intravascular ultrasound guidance for percutaneous coronary intervention in intermediate coronary stenoses: A systematic review and meta‐analysis

Precision Medical Sciences, Volume 15, Issue 2, Page 102-112, June 2026.
Fractional Flow Reserve versus Intravascular Ultrasound for guiding percutaneous coronary intervention in coronary artery disease: A systematic review and meta‐analysis of 5 studies (over 3,900 patients) showing comparable outcomes in MACE, mortality, and target vessel revascularization.
Sanket Patel, Mirza Muhammad Hadeed Khawar, Mehwish Safdar, Iman Ahsan, Rahul Kumar, Promise Ebube Mbala, Mustafa Abrar Zaman, Salma Frindou, Sabahat Kanwal, Mohammad Issa Ayash, Thomas Viji Pulickal, Sonika Gopathoti, Sai Erambalur, Lima Dalil   +13 more
wiley   +1 more source