Results 111 to 120 of about 26,462 (230)
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann +23 more
wiley +2 more sources
Gi- and Gq-Coupled ADP (P2Y) Receptors Act in Opposition to Modulate Nociceptive Signaling and Inflammatory Pain Behavior [PDF]
, 2010 Background Investigations of nucleotide signaling in nociception to date have focused on actions of adenosine triphosphate (ATP). Both ATP-gated ion channels (P2X receptors) and G protein-coupled (P2Y) receptors contribute to nociceptive signaling in ...
Sacha A Malin, Derek C Molliver
core +1 more source
Pharmacogenomics of Oral P2Y12 Receptor Blockers
Journal of Pharmacogenomics & Pharmacoproteomics, 2013 Dual antiplatelet therapy of aspirin and a P2Y12 receptor antagonist is the cornerstone of therapy for patients. Thienopyridines (ticlopidine, clopidogrel and prasugrel) are prodrugs that need cytochrome–mediated conversion to active metabolites to block P2Y12 receptors and subsequent ADP-induced platelet aggregation.
openaire +1 more source
Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu +4 more
wiley +1 more source
Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]
, 2015 No abstract ...
Alvarez-Curto, Elisa +4 more
core +1 more source
Research and Scholarly Methods: Scoping Reviews
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 5, May 2026.ABSTRACT Scoping reviews are similar to systematic reviews in that they are designed to be transparent and reproducible processes to answer a question while reducing bias. The key difference between scoping reviews and the better‐known systematic review method is the scope of the question being answered.
Jason B. Reed +2 more
wiley +1 more source
Chinese Medical Journal, 2019 . Objective:. Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment in patients with acute coronary syndromes (ACS) and in those undergoing percutaneous coronary intervention (PCI).
Ya-Ling Han, Yuan-Yuan Ji
doaj +1 more source
P2Y12 platelet receptors: importance in percutaneous coronary intervention [PDF]
, 2013 Apart from their role in hemostasis and thrombosis, platelets are involved in many other biological processes such as wound healing and angiogenesis. Percutaneous coronary intervention is a highly thrombogenic procedure inducing platelets and monocytes ...
Alves, Claudia Maria Rodrigues +5 more
core +4 more sources
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
Российский кардиологический журнал, 2019 The conclusion of the Expert Council reports an agreement on the place of the P2Y12 receptor blocker prasugrel in the early invasive treatment of patients with acute coronary syndrome ACS, according to the results of the multicenter randomized controlled
S. N. Tereshchenko +24 more
doaj +1 more source