Results 11 to 20 of about 1,255,934 (217)

The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration

Platelets, 2022
Here, we report the in vitro characterization of the P2Y12 receptor antagonist selatogrel (ACT-246475). Binding studies with radiolabeled selatogrel demonstrated that selatogrel is a competitive antagonist of ADP binding to the P2Y12 receptor with a fast
Martine Baumann, Benoît Lack, Isabelle Guillaumat, Mark J. Murphy, Markus A. Riederer   +4 more
doaj   +2 more sources

P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells [PDF]

Scientific Reports, 2021
P2Y12 blockade improves patient outcomes after myocardial infarction. As well as antithrombotic effects, anti-inflammatory effects may contribute to this beneficial clinical outcome.
Patrick M. Siegel, Laura Sander, Alba Fricke, Johannes Stamm, Xiaowei Wang, Prerna Sharma, Nicole Bassler, Ya-Lan Ying, Christoph B. Olivier, Steffen U. Eisenhardt, Christoph Bode, Ingo Ahrens, Philipp Diehl, Karlheinz Peter   +13 more
doaj   +2 more sources

Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12 and P2Y13 receptors in neuropathic pain rats

Journal of Neuroinflammation, 2017
Background More evidence suggests that dorsal spinal cord microglia is an important site contributing to CB2 receptor-mediated analgesia. The upregulation of P2Y12 and P2Y13 purinoceptors in spinal dorsal horn microglia is involved in the development of ...
Juan Niu, Dujuan Huang, Rui Zhou, MingXia Yue, Tao Xu, Junna Yang, Li He, Hong Tian, XiaoHong Liu, Junwei Zeng   +9 more
doaj   +2 more sources

NICHE OF PRASUGREL AMONG OTHER PLATELET P2Y12-RECEPTOR INHIBITORS [PDF]

Атеротромбоз, 2017
Platelet P2Y12-receptor inhibitors are ranked 2nd in terms of administration frequency among antiplatelet agents (after acetylsalicylic acid). Administration of such drugs is mandatory in conditions characterized by increased activation of platelets ...
P. S. LAGUTA, E. P. PANCHENKO
doaj   +2 more sources

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +2 more sources

Ticagrelor: Effects Beyond the P2Y12 Receptor.

Interventional cardiology clinics, 2017
Platelet P2Y12 receptor inhibitors are crucial in the treatment of patients with acute coronary syndrome or undergoing percutaneous coronary intervention. Ticagrelor is a reversibly binding, potent oral P2Y12 inhibitor that also is a weak inhibitor of the equilibrative nucleoside transporter-1 pathway for cellular adenosine uptake.
Sumaya, W., Storey, R.F.
openaire   +4 more sources

Membrane Environment Modulates Ligand-Binding Propensity of P2Y12 Receptor. [PDF]

Pharmaceutics, 2021
The binding of natural ligands and synthetic drugs to the P2Y12 receptor is of great interest because of its crucial role in platelets activation and the therapy of arterial thrombosis.
Haghighi F, Yesylevskyy S, Davani S, Ramseyer C.   +3 more
europepmc   +2 more sources

P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia

Journal of Pain Research, 2017
Pei-Wen Liu,* Ming-Xia Yue,* Rui Zhou, Juan Niu, Du-Juan Huang, Tao Xu, Pei Luo, Xiao-Hong Liu, Jun-Wei Zeng Department of Physiology, Zunyi Medical College, Guizhou, China *These authors contributed equally to ...
Liu P, Yue M, Zhou R, Niu J, Huang D, Xu T, Luo P, Liu X, Zeng J   +8 more
doaj   +1 more source

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Kennedy, Charles, Gurney, Alison M.   +2 more
core   +5 more sources

P2Y12 Antagonists in Cardiovascular Disease—Finding the Best Balance Between Preventing Ischemic Events and Causing Bleeding

Frontiers in Cardiovascular Medicine, 2022
Dual antiplatelet therapy comprising of aspirin and oral P2Y12 receptor antagonists are an established cornerstone of therapy in acute coronary syndromes and percutaneous coronary intervention.
Himawan Fernando, Himawan Fernando, Himawan Fernando, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Xiaowei Wang, Xiaowei Wang, Xiaowei Wang, James Shaw, James Shaw, Dion Stub, Dion Stub, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +17 more
doaj   +1 more source