Results 21 to 30 of about 18,821 (231)

P2Y12 receptor gene polymorphisms are associated with epilepsy. [PDF]

Purinergic Signal, 2023
AbstractThe basic research indicated that microglial P2Y12 receptors (P2Y12Rs) are involved in the pathophysiology of epilepsy through regulated microglial-neuronal interactions, aberrant neurogenesis, or immature neuronal projections. However, whether the clinic case of epilepsy would be associated with P2Y12 receptor gene polymorphisms is presented ...
Wang Q, Shi NR, Lv P, Liu J, Zhang JZ, Deng BL, Zuo YQ, Yang J, Wang X, Chen X, Hu XM, Liu TT, Liu J.   +12 more
europepmc   +4 more sources

P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia

Journal of Pain Research, 2017
Pei-Wen Liu,* Ming-Xia Yue,* Rui Zhou, Juan Niu, Du-Juan Huang, Tao Xu, Pei Luo, Xiao-Hong Liu, Jun-Wei Zeng Department of Physiology, Zunyi Medical College, Guizhou, China *These authors contributed equally to ...
Liu P, Yue M, Zhou R, Niu J, Huang D, Xu T, Luo P, Liu X, Zeng J   +8 more
doaj   +1 more source

Membrane Environment Modulates Ligand-Binding Propensity of P2Y12 Receptor. [PDF]

Pharmaceutics, 2021
The binding of natural ligands and synthetic drugs to the P2Y12 receptor is of great interest because of its crucial role in platelets activation and the therapy of arterial thrombosis.
Haghighi F, Yesylevskyy S, Davani S, Ramseyer C.   +3 more
europepmc   +2 more sources

P2Y12 Antagonists in Cardiovascular Disease—Finding the Best Balance Between Preventing Ischemic Events and Causing Bleeding

Frontiers in Cardiovascular Medicine, 2022
Dual antiplatelet therapy comprising of aspirin and oral P2Y12 receptor antagonists are an established cornerstone of therapy in acute coronary syndromes and percutaneous coronary intervention.
Himawan Fernando, Himawan Fernando, Himawan Fernando, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Xiaowei Wang, Xiaowei Wang, Xiaowei Wang, James Shaw, James Shaw, Dion Stub, Dion Stub, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +17 more
doaj   +1 more source

Cangrelor in STEMI as a bridge to CABG- a mini-case series

American Heart Journal Plus, 2022
Background: Patients with STEMI receive dual antiplatelet therapy as soon as possible with aspirin and a P2Y12 receptor antagonist prior to PCI. A fraction of these patients may have multi-vessel disease needing emergent CABG surgery.
Bishesh Shrestha, Daniel Katz, John Kelley, Dhananjai Menzies, Mun K. Hong   +4 more
doaj   +1 more source

P2Y12 receptor inhibitor plus aspirin versus aspirin treated within 24 hours of acute noncardioembolic ischemic stroke or TIA: Meta-analysis

Journal of the Formosan Medical Association, 2022
Background/Purpose: Antiplatelet therapy is the cornerstone for acute ischemic stroke or transient ischemic attack (TIA). The purpose of this study was to conduct a meta-analysis to assess the efficacy and safety of P2Y12 receptor inhibitor plus aspirin ...
Wen-Yi Huang, Bruce Ovbiagele, Meng Lee
doaj   +1 more source

P2Y12 Receptors in Tumorigenesis and Metastasis [PDF]

Frontiers in Pharmacology, 2018
Platelets, beyond their role in hemostasis and thrombosis, may sustain tumorigenesis and metastasis. These effects may occur via direct interaction of platelets with cancer and stromal cells and by the release of several platelet products. Platelets and tumor cells release several bioactive molecules among which a great amount of adenosine triphosphate
Patrizia Ballerini, Patrizia Ballerini, Melania Dovizio, Melania Dovizio, Annalisa Bruno, Annalisa Bruno, Stefania Tacconelli, Stefania Tacconelli, Paola Patrignani, Paola Patrignani   +9 more
openaire   +3 more sources

Association between P2Y12 inhibitor reloading and in-hospital outcomes for patients with non-ST-segment elevation acute coronary syndrome already on chronic P2Y12 receptor inhibitors therapy in China: findings from the CCC–ACS (improving care for cardiovascular disease in China-acute coronary syndrome) project

European Journal of Medical Research, 2023
Background The association between P2Y12 receptor inhibitors reloading and in-hospital outcomes in non-ST-segment elevation acute coronary syndrome (NSTEACS) patients who were on chronic P2Y12 receptor inhibitors therapy remained underdetermined. Methods
Yintang Wang, Yu Geng, Ou Zhang, Qin Xu, Yajun Xue, Boda Zhou, Ping Zhang, the CCC-ACS Investigators   +7 more
doaj   +1 more source

Platelet P2Y12 Receptor Deletion or Pharmacological Inhibition does not Protect Mice from Sepsis or Septic Shock

TH Open, 2021
Introduction Platelets are increasingly appreciated as key effectors during sepsis, raising the question of the usefulness of antiplatelet drugs to treat patients with sepsis. Objective Evaluate the potential contribution of the platelet P2Y12
Yannick Rabouel, Stéphanie Magnenat, Xavier Delabranche, Christian Gachet, Beatrice Hechler   +4 more
doaj   +1 more source

Arrestin Scaffolds NHERF1 to the P2Y12 Receptor to Regulate Receptor Internalization [PDF]

Journal of Biological Chemistry, 2012
We have recently shown in a patient with mild bleeding that the PDZ-binding motif of the platelet G protein-coupled P2Y(12) receptor (P2Y(12)R) is required for effective receptor traffic in human platelets. In this study we show for the first time that the PDZ motif-binding protein NHERF1 exerts a major role in potentiating G protein-coupled receptor ...
Nisar, Shaista P, Cunningham, Margaret, Saxena, Kunal, Pope, Robert J, Kelly, Eamonn, Mundell, Stuart J   +5 more
openaire   +4 more sources