Results 21 to 30 of about 1,255,934 (217)

Cangrelor in STEMI as a bridge to CABG- a mini-case series

American Heart Journal Plus, 2022
Background: Patients with STEMI receive dual antiplatelet therapy as soon as possible with aspirin and a P2Y12 receptor antagonist prior to PCI. A fraction of these patients may have multi-vessel disease needing emergent CABG surgery.
Bishesh Shrestha, Daniel Katz, John Kelley, Dhananjai Menzies, Mun K. Hong   +4 more
doaj   +1 more source

P2Y12 receptor inhibitor plus aspirin versus aspirin treated within 24 hours of acute noncardioembolic ischemic stroke or TIA: Meta-analysis

Journal of the Formosan Medical Association, 2022
Background/Purpose: Antiplatelet therapy is the cornerstone for acute ischemic stroke or transient ischemic attack (TIA). The purpose of this study was to conduct a meta-analysis to assess the efficacy and safety of P2Y12 receptor inhibitor plus aspirin ...
Wen-Yi Huang, Bruce Ovbiagele, Meng Lee
doaj   +1 more source

Association between P2Y12 inhibitor reloading and in-hospital outcomes for patients with non-ST-segment elevation acute coronary syndrome already on chronic P2Y12 receptor inhibitors therapy in China: findings from the CCC–ACS (improving care for cardiovascular disease in China-acute coronary syndrome) project

European Journal of Medical Research, 2023
Background The association between P2Y12 receptor inhibitors reloading and in-hospital outcomes in non-ST-segment elevation acute coronary syndrome (NSTEACS) patients who were on chronic P2Y12 receptor inhibitors therapy remained underdetermined. Methods
Yintang Wang, Yu Geng, Ou Zhang, Qin Xu, Yajun Xue, Boda Zhou, Ping Zhang, the CCC-ACS Investigators   +7 more
doaj   +1 more source

Platelet P2Y12 Receptor Deletion or Pharmacological Inhibition does not Protect Mice from Sepsis or Septic Shock

TH Open, 2021
Introduction Platelets are increasingly appreciated as key effectors during sepsis, raising the question of the usefulness of antiplatelet drugs to treat patients with sepsis. Objective Evaluate the potential contribution of the platelet P2Y12
Yannick Rabouel, Stéphanie Magnenat, Xavier Delabranche, Christian Gachet, Beatrice Hechler   +4 more
doaj   +1 more source

P2Y12 Receptors in Tumorigenesis and Metastasis [PDF]

Frontiers in Pharmacology, 2018
Platelets, beyond their role in hemostasis and thrombosis, may sustain tumorigenesis and metastasis. These effects may occur via direct interaction of platelets with cancer and stromal cells and by the release of several platelet products. Platelets and tumor cells release several bioactive molecules among which a great amount of adenosine triphosphate
Patrizia Ballerini, Patrizia Ballerini, Melania Dovizio, Melania Dovizio, Annalisa Bruno, Annalisa Bruno, Stefania Tacconelli, Stefania Tacconelli, Paola Patrignani, Paola Patrignani   +9 more
openaire   +3 more sources

Anti-platelet therapy: ADP receptor antagonists. [PDF]

, 2011
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD, Stan Heptinstall, Yanushi Dullewe Wijeyeratne   +3 more
core   +1 more source

Baicalin Depresses the Sympathoexcitatory Reflex Induced by Myocardial Ischemia via the Dorsal Root Ganglia

Frontiers in Physiology, 2018
Myocardial ischemia (MI) is one of the major causes of death in cardiac diseases. Purinergic signaling is involved in bidirectional neuronal-glial communication in the primary sensory ganglia.
Lifang Zou, Lifang Zou, Xinyao Han, Shuangmei Liu, Shuangmei Liu, Yingxin Gong, Bing Wu, Bing Wu, Zhihua Yi, Zhihua Yi, Hui Liu, Hui Liu, Shanhong Zhao, Shanhong Zhao, Tianyu Jia, Tianyu Jia, Lin Li, Lin Li, Huilong Yuan, Huilong Yuan, Liran Shi, Liran Shi, Chunping Zhang, Chunping Zhang, Yun Gao, Yun Gao, Guilin Li, Guilin Li, Hong Xu, Hong Xu, Shangdong Liang, Shangdong Liang   +31 more
doaj   +1 more source

Arrestin Scaffolds NHERF1 to the P2Y12 Receptor to Regulate Receptor Internalization [PDF]

Journal of Biological Chemistry, 2012
We have recently shown in a patient with mild bleeding that the PDZ-binding motif of the platelet G protein-coupled P2Y(12) receptor (P2Y(12)R) is required for effective receptor traffic in human platelets. In this study we show for the first time that the PDZ motif-binding protein NHERF1 exerts a major role in potentiating G protein-coupled receptor ...
Nisar, Shaista P, Cunningham, Margaret, Saxena, Kunal, Pope, Robert J, Kelly, Eamonn, Mundell, Stuart J   +5 more
openaire   +4 more sources

Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes.

PLoS ONE, 2013
Leukotriene E4 (LTE4), the most stable of the cysteinyl leukotrienes (cysLTs), binds poorly to classical type 1 and 2 cysLT receptors although in asthmatic individuals it may potently induce bronchial constriction, airway hyperresponsiveness and ...
Holly R Foster, Elisabeth Fuerst, Tak H Lee, Davis J Cousins, Grzegorz Woszczek   +4 more
doaj   +1 more source

Early discontinuation of dual antiplatelet therapy via acetylsalicylic acid cessation in patients with acute coronary syndrome undergoing percutaneous coronary interventions to reduce the bleeding risk

Российский кардиологический журнал, 2021
Early percutaneous coronary intervention (PCI) and long-term aggressive antithrombotic treatment based on dual antiplatelet therapy (DAPT) are the most important elements in the treatment of patients with acute coronary syndrome (ACS).
O. V. Averkov
doaj   +1 more source