Results 31 to 40 of about 18,821 (231)
Role and recent progress of P2Y12 receptor in cancer development. [PDF]
Purinergic SignalP2Y12 receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet function, hemostasis, and thrombosis. P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis, and affect the tumor immune microenvironment (TIME) and tumor drug resistance, which ...
Xi Y, Min Z, Liu M, Lin X, Yuan ZH.
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P2Y12 receptor in platelet activation
Platelets, 2011 ADP plays an important role in hemostasis and thrombosis. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and thrombus formation. Thus, the P2Y12 receptor has been an effective target for antithrombotic drugs.
Soochong, Kim, Satya P, Kunapuli
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Frontiers in Physiology, 2018 Myocardial ischemia (MI) is one of the major causes of death in cardiac diseases. Purinergic signaling is involved in bidirectional neuronal-glial communication in the primary sensory ganglia.
Lifang Zou +31 more
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Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes.
PLoS ONE, 2013 Leukotriene E4 (LTE4), the most stable of the cysteinyl leukotrienes (cysLTs), binds poorly to classical type 1 and 2 cysLT receptors although in asthmatic individuals it may potently induce bronchial constriction, airway hyperresponsiveness and ...
Holly R Foster +4 more
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Российский кардиологический журнал, 2021 Early percutaneous coronary intervention (PCI) and long-term aggressive antithrombotic treatment based on dual antiplatelet therapy (DAPT) are the most important elements in the treatment of patients with acute coronary syndrome (ACS).
O. V. Averkov
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Selatogrel is a potent and reversible P2Y12 receptor antagonist developed for subcutaneous self‐administration by patients with suspected acute myocardial infarction.
Andrea Henrich +3 more
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Central role of the P2Y12 receptor in platelet activation [PDF]
Journal of Clinical Investigation, 2004 Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic
Robert T, Dorsam, Satya P, Kunapuli
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Insights into platelet P2Y12 receptor activation [PDF]
Blood, 2015 In this issue of Blood , Lecchi et al report that lifelong abnormal bleeding episodes in 2 brothers are the result of a homozygous mutation in the gene encoding the P2Y12 receptor that disrupts adenosine diphosphate (ADP)–promoted platelet aggregation.[1][1] ![Figure][2] ADP ...
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Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
, 2005 Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn +9 more
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P2 Receptors and Platelet Activation
The Scientific World Journal, 2002 Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors.
Satva P. Kunapuli
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