Results 31 to 40 of about 26,462 (230)

Pharmacokinetic/pharmacodynamic modeling of drug interactions at the P2Y12 receptor between selatogrel and oral P2Y12 antagonists

CPT: Pharmacometrics & Systems Pharmacology, 2021
Selatogrel is a potent and reversible P2Y12 receptor antagonist developed for subcutaneous self‐administration by patients with suspected acute myocardial infarction.
Andrea Henrich, Christian Hove Claussen, Jasper Dingemanse, Andreas Krause   +3 more
doaj   +1 more source

P2Y12 receptor modulation of ADP‐evoked intracellular Ca2+ signalling in THP‐1 human monocytic cells [PDF]

, 2018
Background and purpose: The Gi‐coupled, ADP‐activated P2Y12 receptor is well characterised as playing a key role in platelet activation via crosstalk with P2Y1 in ADP‐evoked intracellular Ca2+ response.
Alexander, Alexander, Aungraheeta, Baqi, Ben Addi, Brinson, Campwala, Cattaneo, Communi, Communi, Curtis, Czerniecki, Dorsam, Erb, Giezen, Harding, Hardy, Husted, Jin, Kronlage, Mahaut-Smith, Mamedova, Mattana, Myers, Nylander, Sivaramakrishnan, Suplat, West, Zhang, Ziegler-Heitbrock   +29 more
core   +1 more source

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Insights into platelet P2Y12 receptor activation [PDF]

Blood, 2015
In this issue of Blood , Lecchi et al report that lifelong abnormal bleeding episodes in 2 brothers are the result of a homozygous mutation in the gene encoding the P2Y12 receptor that disrupts adenosine diphosphate (ADP)–promoted platelet aggregation.[1][1] ![Figure][2] ADP ...
openaire   +2 more sources

Arrestin Scaffolds NHERF1 to the P2Y12 Receptor to Regulate Receptor Internalization [PDF]

Journal of Biological Chemistry, 2012
We have recently shown in a patient with mild bleeding that the PDZ-binding motif of the platelet G protein-coupled P2Y(12) receptor (P2Y(12)R) is required for effective receptor traffic in human platelets. In this study we show for the first time that the PDZ motif-binding protein NHERF1 exerts a major role in potentiating G protein-coupled receptor ...
Nisar, Shaista P, Cunningham, Margaret, Saxena, Kunal, Pope, Robert J, Kelly, Eamonn, Mundell, Stuart J   +5 more
openaire   +3 more sources

Platelets at the vascular interface [PDF]

, 2018
..
Bergmeier, Wolfgang, Stefanini, Lucia
core   +1 more source

A hopeful therapy for Niemann-Pick C diseases [PDF]

, 2017
Not abstract ...
Erickson, Robert P., Fiorenza, Maria Teresa   +1 more
core   +1 more source

P2 Receptors and Platelet Activation

The Scientific World Journal, 2002
Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors.
Satva P. Kunapuli
doaj   +1 more source

Platelet signaling--blood's great balancing act [PDF]

, 2015
The antagonistic balance between CalDAG-GEFI and RASA3 signaling is critical for the fine-tuning of platelet adhesiveness, both in the circulation and at sites of vascular ...
Bergmeier, Wolfgang, Stefanini, Lucia
core   +2 more sources