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P2Y12 receptor in platelet activation
Platelets, 2011 ADP plays an important role in hemostasis and thrombosis. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and thrombus formation. Thus, the P2Y12 receptor has been an effective target for antithrombotic drugs.
Soochong, Kim, Satya P, Kunapuli
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Selatogrel is a potent and reversible P2Y12 receptor antagonist developed for subcutaneous self‐administration by patients with suspected acute myocardial infarction.
Andrea Henrich +3 more
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Central role of the P2Y12 receptor in platelet activation [PDF]
Journal of Clinical Investigation, 2004 Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic
Robert T, Dorsam, Satya P, Kunapuli
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Insights into platelet P2Y12 receptor activation [PDF]
Blood, 2015 In this issue of Blood , Lecchi et al report that lifelong abnormal bleeding episodes in 2 brothers are the result of a homozygous mutation in the gene encoding the P2Y12 receptor that disrupts adenosine diphosphate (ADP)–promoted platelet aggregation.[1][1] ![Figure][2] ADP ...
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P2 Receptors and Platelet Activation
The Scientific World Journal, 2002 Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors.
Satva P. Kunapuli
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P2Y1 and P2Y12 receptor heterodimerisation : from recombinant systems to native detection [PDF]
, 2018 Purinergic P2Y1 and P2Y12 receptors belong to the class A family of transmembrane G‐protein coupled receptors (GPCRs) and have been demonstrated to exist as homodimers and oligomers and form heterodimers with other GPCRs.
Murray, J.F. +33 more
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Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]
, 2007 Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
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Journal of Interventional Cardiology, 2021 Introduction. This network meta-analysis aimed to evaluate the efficacy and safety of different dual antiplatelet therapies (DAPTs) after percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods.
Yi Xu +4 more
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P2Y12 receptor modulation of ADP‐evoked intracellular Ca2+ signalling in THP-1 human monocytic cells [PDF]
, 2018 Background and purpose: The Gi‐coupled, ADP‐activated P2Y12 receptor is well characterised as playing a key role in platelet activation via crosstalk with P2Y1 in ADP‐evoked intracellular Ca2+ response.
J J Micklewright +5 more
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Response variability to P2Y12 receptor inhibitors: expectations and reality.
JACC. Cardiovascular interventions, 2013 P2Y12 inhibitors are widely used in patients with acute coronary syndromes and in the secondary prevention of thrombotic events in vascular diseases. Within the past few years, several pharmacological, genetic, and clinical limitations of the second-generation thienopyridine clopidogrel have raised major concerns. High on-treatment platelet reactivity,
Siller-Matula, Jolanta M +6 more
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