Results 51 to 60 of about 1,255,934 (217)

Genotype-Guided Use of P2Y12 Inhibitors: A Review of Current State of the Art

Frontiers in Cardiovascular Medicine, 2022
The pharmacodynamics of the purinergic receptor type Y, subtype 12 (P2Y12) inhibitors has evolved. Our understanding of the metabolism of P2Y12 inhibitors has revealed polymorphisms that impact drug metabolism and antiplatelet efficacy, leading to ...
Abdullah Al-abcha, Yasser Radwan, Danielle Blais, Ernest L. Mazzaferri, Konstantinos Dean Boudoulas, Essa M. Essa, Richard J. Gumina   +6 more
doaj   +1 more source

Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation

, 2017
Platelet P2Y12 is an important adenosine diphosphate (ADP) receptor that is involved in agonist-induced platelet aggregation and is a valuable target for the development of anti-platelet drugs.
Christian Troidl, Daniel Sedding, Christian Hamm, Dursun Gündüz, Muhammad Aslam, Mariana Parahuleva, Christian Tanislav, Sentot Santoso   +7 more
core   +1 more source

Structure of the human P2Y12 receptor in complex with an antithrombotic drug [PDF]

Nature, 2014
P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human, which are subdivided into P2Y1-like receptors and P2Y12-like receptors.
Kaihua, Zhang, Jin, Zhang, Zhan-Guo, Gao, Dandan, Zhang, Lan, Zhu, Gye Won, Han, Steven M, Moss, Silvia, Paoletta, Evgeny, Kiselev, Weizhen, Lu, Gustavo, Fenalti, Wenru, Zhang, Christa E, Müller, Huaiyu, Yang, Hualiang, Jiang, Vadim, Cherezov, Vsevolod, Katritch, Kenneth A, Jacobson, Raymond C, Stevens, Beili, Wu, Qiang, Zhao   +20 more
openaire   +2 more sources

Interaction of Operator−Patient Sex on Peri‐Procedural Treatments and Major Coronary Outcomes After Percutaneous Coronary Intervention

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background There are limited data evaluating the association between operator−patient sex, and outcomes in patients undergoing percutaneous coronary intervention (PCI). Methods We included 138,112 consecutive PCI procedures in patients presenting with acute coronary syndrome (ACS) in England and Wales, 2017−2020.
Sharon A. Ayayo, Vicky P. Taxiarchi, Angela Jerath, Evangelos Kontopantelis, Sonya N. Burgess, Sarah Zaman, Mamas A. Mamas   +6 more
wiley   +1 more source

Clinical Outcomes of Drug‐Eluting Stents and Drug‐Coated Balloons in Tortuous Small Coronary Lesions

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background In small, tortuous coronary lesions, the long‐term comparative performance of drug‐coated balloon (DCB) angioplasty versus drug‐eluting stent (DES) treatment remains uncertain, despite both strategies being widely used in contemporary percutaneous coronary intervention (PCI) practice. Aims This study aimed to compare 3‐year clinical
Shunichiro Ishio, Takashi Nagasaka, Ryota Taniuchi, Shiro Amanai, Yohei Ishibashi, Noriaki Takama, Hideki Ishii   +6 more
wiley   +1 more source

Primary Percutaneous Coronary Intervention Guided by High‐Definition Intravascular Ultrasound (The SPECTRUM Study)

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Limited data are available on the use of intravascular ultrasound (IVUS) in patients presenting with ST‐segment elevation myocardial infarction (STEMI). Aims This study aimed to assess the impact of IVUS‐guided primary percutaneous coronary intervention (PCI).
Frederik T. W. Groenland, Annemieke C. Ziedses des Plantes, Tara Neleman, Jurgen M. R. Ligthart, Karen T. Witberg, Rutger‐Jan Nuis, Jeroen M. Wilschut, Roberto Diletti, Wijnand K. den Dekker, Isabella Kardys, Paul Cummins, Karim D. Mahmoud, Nicolas M. Van Mieghem, Joost Daemen   +13 more
wiley   +1 more source

Temporal Trends and Prognosis in Rotational Atherectomy: A Comparison of Contemporary and Traditional Eras

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Rotational atherectomy (RA) has undergone considerable technical modernization in recent years. This study evaluated whether RA performed in the contemporary era was associated with superior cardiovascular outcomes compared with the traditional era. Aims To compare the clinical characteristics and cardiovascular outcomes of patients
Ravi Vazirani, Gonzalo García‐Martí, Andrés Provencio‐Regidor, Irene Serrano‐García, Adrián Jerónimo‐Baza, Alejandro Travieso, Gabriela Tirado‐Conte, Fernando Macaya‐Ten, Hernán Mejía‐Rentería, Pablo Salinas, Luis Nombela‐Franco, Pilar Jiménez‐Quevedo, Nieves Gonzalo, Javier Escaned, Antonio Fernández‐Ortiz, Iván J. Núñez‐Gil   +15 more
wiley   +1 more source

Impact of Intravenous P2Y12-Receptor Inhibition with Cangrelor in Patients Presenting with Acute Coronary Syndrome and Cardiogenic Shock – a Case Series

Cellular Physiology and Biochemistry, 2017
Background/Aims: Patients with acute coronary syndromes (ACS) presenting with cardiogenic shock (CS) are at particular risk for death and adverse cardiac events.
Michal Droppa, Oliver Borst, Dominik Rath, Karin Müller, Meinrad Gawaz, Deepak L. Bhatt, Tobia Geisler   +6 more
doaj   +1 more source

ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors

Pharmaceuticals, 2020
This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5′-diphosphate (ADP, 100 µmol·L−1) Platelet-rich plasma (PRP ...
Ronald Anderson, Annette J. Theron, Helen C. Steel, Jan G. Nel, Gregory R. Tintinger   +4 more
doaj   +1 more source

Antagonizing P2Y12 Receptor Inhibitors: Current and Future Options [PDF]

Thrombosis and Haemostasis, 2019
AbstractThere are clinical scenarios where the balance between the risk of ischemic and bleeding events leads to the clinical decision to reverse the antiplatelet effect of P2Y12 receptor inhibitors. These scenarios comprise emergency situations such as active severe bleeding, urgent procedures with presumed high bleeding risk, or major trauma with ...
Trenk, Dietmar, Hille, Laura, Leggewie, Stefan, Stratz, Christian, Nührenberg, Thomas G., Aradi, Daniel, Schrör, Karsten, Sibbing, Dirk   +7 more
openaire   +3 more sources