Results 61 to 70 of about 1,255,934 (217)

Unprotected Left Main Disease: Clinical Outcomes Following Deferral, Coronary Artery Bypass Grafting, or Percutaneous Coronary Intervention

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The prognostic benefit of revascularization for unprotected left main (LM) disease remains uncertain, as guideline endorsement of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) precludes comparison with deferral, which is unlikely to be assessed in a randomized trial.
Marc Meller Bröchner, Evald Høj Christiansen, Kristian Kragholm, Lisette Okkels Jensen, Gennady Atroshchenko, Ivy Susanne Modrau, Lars Riber, Oliver Buchhave Pedersen, Leif Thuesen, Christian Torp‐Pedersen, Ashkan Eftekhari   +10 more
wiley   +1 more source

The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration

Frontiers in Pharmacology, 2018
The accumulation of partially degraded lipid waste in lysosomal-related organelles may contribute to pathology in many aging diseases. The presence of these lipofuscin granules is particularly evident in the autofluorescent lysosome-associated organelles
Wennan Lu, Néstor M. Gómez, Jason C. Lim, Sonia Guha, Sonia Guha, Ann O’Brien-Jenkins, Erin E. Coffey, Keith E. Campagno, Stuart A. McCaughey, Alan M. Laties, Leif G. Carlsson, Claire H. Mitchell, Claire H. Mitchell, Claire H. Mitchell   +13 more
doaj   +1 more source

Ticagrelor Can Regulate the Ion Channel Characteristics of Superior Cervical Ganglion Neurons after Myocardial Infarction

Journal of Cardiovascular Development and Disease, 2023
Background: The superior cervical ganglion (SCG) plays a key role in cardiovascular diseases. The aim of this study was to determine the changes in the ion channel characteristics of the SCG following myocardial infarction (MI) and the role of ...
Lijun Cheng, Lin Yu, Xiaoping Zhan, Gary Tse, Tong Liu, Huaying Fu, Guangping Li   +6 more
doaj   +1 more source

Diagnostic Agreement and Threshold Correspondence Between Resting Full‐Cycle Ratio and Nicorandil‐Based Fractional Flow Reserve in Intermediate Coronary Stenosis: A Prospective Single‐Center Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background RFR has shown good aggregate agreement with FFR, including in prior Asian cohorts using intracoronary nicorandil. Where RFR‐FFR disagreement is concentrated relative to the FFR 0.80 decision boundary, and how the two binary thresholds correspond, remain incompletely characterized. Methods In a prospective single‐center registry, 300
Yonghoon Shin, Onyou Kim, Gi Won Yu, Yun Won Lee, Jung‐Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu   +8 more
wiley   +1 more source

P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention. [PDF]

, 2022
For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic pharmacology after percutaneous coronary intervention (PCI).
Bhatt, Deepak, Gibson, C. Michael, Steg, Philippe G, Watanabe, Hirotoshi, Storey, Robert, Capodanno, Davide, Serruys, Patrick, Rao, Sunil V, Kastrati, Adnan, Lopes, Renato, O’donoghue, Michelle, Steg, Philippe G., Steg, Philippe Gabriel, Vranckx, Pascal, O'Donoghue, Michelle L., Angiolillo, Dominick J., Gibson, C Michael, Gwon, Hyeon-Cheol, Rao, Sunil, Rollini, Fabiana, Dangas, George, Storey, Robert F, Angiolillo, Dominick J, Bhatt, Deepak L., Rao, Sunil, V, Windecker, Stephan, Lemos, Pedro A., Bhatt, Deepak L, Storey, Robert F., Lopes, Renato D, Baber, Usman, Angiolillo, Dominick, Lemos, Pedro, Kimura, Takeshi, Collet, Jean-Philippe, Franchi, Francesco, Lopes, Renato D., Serruys, Patrick W., Lemos, Pedro A, Mehran, Roxana, Serruys, Patrick W, Valgimigli, Marco, O'Donoghue, Michelle L   +42 more
core   +1 more source

The in‐hospital administration of sacubitril/valsartan in acute myocardial infarction: A meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 998-1012, April 2025.
In patients with Acute Myocardial Infarction related heart failure, the in‐hospital administration of ARNIs was associated with a reduced risk of MACEs and re‐hospitalizations for heart failure, as well as cardiac remodeling, compared to standard therapy.
Gianluca Di Pietro, Riccardo Improta, Paolo Severino, Andrea D'Amato, Lucia Ilaria Birtolo, Ovidio De Filippo, Antonio Lattanzio, Raffaele De Cristofaro, Giacchino Galardo, Fabrizio D'Ascenzo, Roberto Badagliacca, Gennaro Sardella, Maurizio Volterrani, Francesco Fedele, Carmine Dario Vizza, Massimo Mancone   +15 more
wiley   +1 more source

Differential endosomal sorting of a novel P2Y12 purinoreceptor mutant

, 2013
P2Y12 receptor internalization and recycling play an essential role in ADP-induced platelet activation. Recently, we identified a patient with a mild bleeding disorder carrying a heterozygous mutation of P2Y12 (P341A) whose P2Y12 receptor recycling was ...
Mundell, Stuart J, Cunningham, Margaret R, Cooke, Alexandra E, Nisar, Shaista P, Emery, Elizabeth D   +4 more
core   +4 more sources

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Personalized antiplatelet therapy with P2Y12 receptor inhibitors: benefits and pitfalls. [PDF]

, 2015
Antiplatelet therapy with P2Y12 receptor inhibitors has become the cornerstone of medical treatment in patients with acute coronary syndrome, after percutaneous coronary intervention and in secondary prevention of atherothrombotic events.
Siller-Matula, Jolanta, Kubica, Jacek, Kozinski, Marek, Aradi, Dániel, Winter, Max-Paul   +4 more
core   +1 more source

Silencing P2Y12 and P2Y13 receptors rehabilitates the ADP-induced P2Y1-mediated osteogenic commitment of post-menopausal mesenchymal stromal cells

Cell Communication and Signaling
Background Participation of ADP-sensitive metabotropic P2Y1, P2Y12 and P2Y13 receptors in human osteogenesis is controversial. Here, we investigated the variations in the expression and bone-forming properties of the P2Y1R in osteogenic-differentiating ...
Catarina Bessa-Andrês, Rui Pinto-Cardoso, Maria Adelina Costa, Fátima Ferreirinha, José Marinhas, Rolando Freitas, Rui Lemos, Diogo Catelas, Adélio Vilaça, António Oliveira, Paulo Correia-de-Sá, José Bernardo Noronha-Matos   +11 more
doaj   +1 more source