Results 71 to 80 of about 18,821 (231)

The in‐hospital administration of sacubitril/valsartan in acute myocardial infarction: A meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 998-1012, April 2025.
In patients with Acute Myocardial Infarction related heart failure, the in‐hospital administration of ARNIs was associated with a reduced risk of MACEs and re‐hospitalizations for heart failure, as well as cardiac remodeling, compared to standard therapy.
Gianluca Di Pietro, Riccardo Improta, Paolo Severino, Andrea D'Amato, Lucia Ilaria Birtolo, Ovidio De Filippo, Antonio Lattanzio, Raffaele De Cristofaro, Giacchino Galardo, Fabrizio D'Ascenzo, Roberto Badagliacca, Gennaro Sardella, Maurizio Volterrani, Francesco Fedele, Carmine Dario Vizza, Massimo Mancone   +15 more
wiley   +1 more source

The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges

, 2023
P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients.
Emmanuel Boadi Amoafo, Elisabetta Liverani, Ying Kang, Torsten Schöneberg, Philomena Entsie   +4 more
core   +1 more source

The effect of smoking on residual platelet reactivity to clopidogrel: a systematic review and meta-analysis

Platelets, 2020
Cigarette smoking is an important cardiovascular risk factor, causing morbidity and mortality. There are many original studies on the impact of smoking, but its influence on platelet ADP-P2Y12 receptor inhibitors lack consistency.
Zhiyan Liu, Qian Xiang, Guangyan Mu, Qiufen Xie, Shuang Zhou, Zining Wang, Shuqing Chen, Kun Hu, Yanjun Gong, Jie Jiang, Yimin Cui   +10 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Long‐term cardiovascular outcomes of immune checkpoint inhibitor‐related myocarditis: A large single‐centre analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1237-1245, April 2025.
Abstract Aims Immune checkpoint inhibitors (ICI) are the cornerstone of modern oncology; however, side effects such as ICI‐related myocarditis (irM) can be fatal. Recently, Bonaca proposed criteria for irM; however, it is unknown if they correlate well with cardiovascular (CV) ICI‐related adverse events.
Lorenzo Braghieri, Ahmad Gharaibeh, Lubika Nkashama, Abdelrahman Abushouk, Osama Abushawer, Amir Mehdizadeh‐Shrifi, Bianca Honnekeri, Cassandra Calabrese, Venu Menon, Pauline Funchain, Patrick Collier, Diego Sadler, Rohit Moudgil   +12 more
wiley   +1 more source

P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention.

, 2022
For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic pharmacology after percutaneous coronary intervention (PCI).
Bhatt, Deepak, Gibson, C. Michael, Steg, Philippe G, Watanabe, Hirotoshi, Storey, Robert, Capodanno, Davide, Serruys, Patrick, Rao, Sunil V, Kastrati, Adnan, Lopes, Renato, O’donoghue, Michelle, Steg, Philippe G., Steg, Philippe Gabriel, Vranckx, Pascal, O'Donoghue, Michelle L., Angiolillo, Dominick J., Gibson, C Michael, Gwon, Hyeon-Cheol, Rao, Sunil, Rollini, Fabiana, Dangas, George, Storey, Robert F, Angiolillo, Dominick J, Bhatt, Deepak L., Rao, Sunil, V, Windecker, Stephan, Lemos, Pedro A., Bhatt, Deepak L, Storey, Robert F., Lopes, Renato D, Baber, Usman, Angiolillo, Dominick, Lemos, Pedro, Kimura, Takeshi, Collet, Jean-Philippe, Franchi, Francesco, Lopes, Renato D., Serruys, Patrick W., Lemos, Pedro A, Mehran, Roxana, Serruys, Patrick W, Valgimigli, Marco, O'Donoghue, Michelle L   +42 more
core   +1 more source

Silencing P2Y12 and P2Y13 receptors rehabilitates the ADP-induced P2Y1-mediated osteogenic commitment of post-menopausal mesenchymal stromal cells

Cell Communication and Signaling
Background Participation of ADP-sensitive metabotropic P2Y1, P2Y12 and P2Y13 receptors in human osteogenesis is controversial. Here, we investigated the variations in the expression and bone-forming properties of the P2Y1R in osteogenic-differentiating ...
Catarina Bessa-Andrês, Rui Pinto-Cardoso, Maria Adelina Costa, Fátima Ferreirinha, José Marinhas, Rolando Freitas, Rui Lemos, Diogo Catelas, Adélio Vilaça, António Oliveira, Paulo Correia-de-Sá, José Bernardo Noronha-Matos   +11 more
doaj   +1 more source

Experimental evidence for the involvement of F0/F1 ATPase and subsequent P2Y12 receptor activation in prothymosin alpha-induced protection of retinal ischemic damage

Journal of Pharmacological Sciences, 2020
The inhibition of retinal ischemia-induced damage by post-ischemic prothymosin alpha (ProTα) was not affected in toll-like receptor 4 knockout (TLR4−/−) mice but blocked by the pretreatment with antibody against F0/F1 ATPase α- or β-subunit, novel ...
Sebok Kumar Halder, Hayato Matsunaga, Hiroshi Ueda   +2 more
doaj   +1 more source

Evaluating the impact of a newly established hospitalist medicine procedure service on length of stay and procedural outcomes: A retrospective propensity‐matched analysis

Journal of Hospital Medicine, EarlyView.
Abstract Background Reliance on interventional radiology (IR) has been associated with delays in procedure completion and prolonged hospital length of stay (LOS). Hospitalist medicine procedure services (HMPS) have been proposed as a strategy to mitigate these inefficiencies, though outcomes of newly established programs composed of physicians with ...
Jeremy Gentile, Saria Alazmeh, Kriti Soni, Tarek Alsibai, Felicia Wright, Alicia Stowe, Fergus Peacock   +6 more
wiley   +1 more source

The Pharmacodynamics of Switching Between P2Y12 Receptor Antagonists

JACC: Cardiovascular Interventions, 2016
The P2Y12 receptor antagonists are key components of the medical and invasive management of coronary artery disease. These agents reduce recurrent cardiovascular events in the setting of acute coronary syndrome (ACS), decrease the incidence of thrombotic events after percutaneous ...
openaire   +2 more sources