Results 111 to 120 of about 20,383 (265)
Pharmaceuticals, 2020 We have shown previously that platelet activity can be lowered through the simultaneous inhibition of P2Y12 receptor and activation of adenosine receptors (AR).
Nina Wolska +4 more
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The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy
Frontiers in Pharmacology, 2018 Epilepsy encompasses a heterogeneous group of neurological syndromes which are characterized by recurrent seizures affecting over 60 million people worldwide.
Mariana Alves +2 more
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BMC Immunology, 2006 Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo +4 more
doaj +1 more source
The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells [PDF]
, 2013 Background: Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release.
Corbalan, J Jose +5 more
core +1 more source
Purinergic Signaling in Mast Cell Degranulation and Asthma
Frontiers in Pharmacology, 2017 Mast cells are responsible for the majority of allergic conditions. It was originally thought that almost all allergic events were mediated directly only via the high-affinity immunoglobulin E receptors.
Zhan-Guo Gao, Kenneth A. Jacobson
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P2X7 Receptor Mediated Increase In Cell Membrane Permeability
Ankara Üniversitesi Tıp Fakültesi Mecmuas, 2018 Purinergic receptors consist of two main families; P2X and P2Y. P2Y receptors are G protein coupled receptors (GPCR), whereas P2X receptors are non-selective cation channels. P2X7 receptors which is a member of P2X receptors, have been found myriad types
Șerife Cankurtaran-Sayar, Kemal Sayar
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Purinergic Signalling and Neurological Diseases: An Update [PDF]
, 2017 Purinergic signalling, i.e. ATP as an extracellular signalling molecule and cotransmitter in both peripheral and central neurons, is involved in the physiology of neurotransmission and neuromodulation.
Burnstock, G
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Regulation of epidermal homeostasis through P2Y2receptors [PDF]
, 1999 C. Jane Dixon +6 more
openalex +1 more source
Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]
, 2008 To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L. +7 more
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The role of dinucleoside polyphosphates on the ocular surface and other eye structures [PDF]
, 2016 Dinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present
Carracedo Rodríguez, Juan Gonzalo +3 more
core +1 more source