Results 101 to 110 of about 688,584 (205)

Hetero-oligomerization of the P2Y 11} and P2Y 1} receptor controls receptor internalization and ligand selectivity of the P2Y 11} receptor

, 2007
Nucleotides signal through purinergic receptors. The nucleotide P2 receptors are subdivided into ionotropic P2X receptors and metabotropic P2Y receptors. The tissue-specificity of nucleotide signaling requires diversity of function within the family of the purinergic receptors.
Ecke, Denise, Hanck, Theodor, Tulapurkar, Mohan, Schäfer, Rainer, Kassack, Matthias, Stricker, Rolf, Reiser, Georg   +6 more
openaire   +1 more source

Ligand-Independent Spontaneous Activation of Purinergic P2Y₆ Receptor Under Cell Culture Soft Substrate

Cells
G protein-coupled receptors (GPCRs) exist in the conformational equilibrium between inactive state and active state, where the proportion of active state in the absence of a ligand determines the basal activity of GPCRs.
Akiyuki Nishimura, Kazuhiro Nishiyama, Tomoya Ito, Xinya Mi, Yuri Kato, Asuka Inoue, Junken Aoki, Motohiro Nishida   +7 more
doaj   +1 more source

The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy

Frontiers in Pharmacology, 2018
Epilepsy encompasses a heterogeneous group of neurological syndromes which are characterized by recurrent seizures affecting over 60 million people worldwide.
Mariana Alves, Edward Beamer, Tobias Engel   +2 more
doaj   +1 more source

Distal colonic Na(+) absorption inhibited by luminal P2Y(2) receptors.

, 2007
Luminal P2 receptors are ubiquitously expressed in transporting epithelia. In steroid-sensitive epithelia (e.g. lung, distal nephron) epithelial Na(+) channel (ENaC)-mediated Na(+) absorption is inhibited via luminal P2 receptors.
Boeynaems, Jean-Marie, Geyti, C S, Sorensen, M V, Robaye, Bernard, Matos, J E, Leipziger, J   +5 more
core   +1 more source

Purinergic Receptor Expression and Potential Association with Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Development

Cell Journal, 2017
Objective: Due to recent progress in production of human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-OPCs) for ameliorating myelin disease such as multiple sclerosis (MS) and the role of purinergic signaling in OPCs development,
Shirin Kashfi, Maryam Peymani, Kamran Ghaedi, Hossein Baharvand, Mohammad Hossein Nasr Esfahani, Mohammad Javan   +5 more
doaj   +1 more source

Recommended tool compounds and drugs for blocking P2X and P2Y receptors. [PDF]

Purinergic Signal, 2021
Müller CE, Namasivayam V.
europepmc   +1 more source

P2Y receptors in GtoPdb v.2025.3 [PDF]

P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [2, 4, 192]) are activated by the endogenous ligands ATP, ADP, UTP, UDP, and UDP-sugars.
Weisman, Gary A., Abbracchio, Maria-Pia, Ceruti, Stefania, King, Brian F., Müller, Christa E., Fumagalli, Marta, Kennedy, Charles, Raffaele, Stefano, Jacobson, Kenneth A., Burnstock, Geoffrey, Inoue, Kazu, Boeynaems, Jean-Marie, Gachet, Christian, Humphries, Robert G., Marangon, Davide, Ralevic, Vera, Boyer, José L., Lecca, Davide, Hills, Rebecca, Miras-Portugal, Maria Teresa, Stefania Ceruti, Christa E. Müller, Marta Fumagalli, Maria Teresa Miras-Portugal, Jean-Marie Boeynaems, Davide Marangon, Stefano Raffaele, José L. Boyer, Gary A. Weisman, Brian F. King, Rebecca Hills, Robert G. Humphries, Kazu Inoue, Kenneth A. Jacobson, Charles Kennedy, Maria-Pia Abbracchio, Vera Ralevic, Geoffrey Burnstock, Christian Gachet, Davide Lecca   +39 more
core   +1 more source

P2Y receptors for extracellular nucleotides: Contributions to cancer progression and therapeutic implications. [PDF]

Biochem Pharmacol, 2021
Woods LT, Forti KM, Shanbhag VC, Camden JM, Weisman GA.   +4 more
europepmc   +1 more source

Protein expression of P2Y₁, P2Y₁₂ and P2Y₁₃ receptors in aortas from control and Ang II-hypertensive rats.

, 2014
(A) representative images of P2Y receptors expression in rat aortas from vehicle-treated control (n = 4) and vehicle-treated Ang II-hypertensive rats (n = 5). (B) Bar graphs showing the relative vascular expression of P2Y receptors after normalization to
Rita C. Tostes (406786), Fernanda R. Giachini (410592), Romulo Leite (538002), R. Clinton Webb (406787), David A. Osmond (538003), Victor V. Lima (538004), Edward W. Inscho (538005)   +6 more
core   +1 more source

Molecular modeling as a tool to investigate molecular recognition in P2Y receptors

, 2002
Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. These effects are mediated through a specific class of plasma membrane receptors called P2 receptors that, according to the molecular structure, are further subdivided
JACOBSON KA, MORO, STEFANO
core   +1 more source