Results 111 to 120 of about 688,584 (205)

P2Y₁ and P2Y₂ receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed

, 2002
1 To assess the role of nucleotide receptors in endothelial-smooth muscle signalling, changes in perfusion pressure of the rat arterial mesenteric bed, the luminal output of nitric oxide (NO) and guanosine 3',5' cyclic monophosphate (cGMP) accumulation ...
Buvinic, S, Briones, R, Huidobro-Toro, JP   +2 more
core  

Uridine diphosphate (UDP) stimulates insulin secretion by activation of P2Y(6) receptors.

, 2008
We examined the transcriptional expression and functional effects of receptors for the extracellular pyrimidines uridine triphosphate (UTP) and uridine diphosphate (UDP), on insulin and glucagon secretion in isolated mouse pancreatic islets and purified ...
Erlinge, David,, Amisten, Stefan,, Salehi, S Albert, Parandeh, Fariborz, Erlinge, David, Abaraviciene, Sandra Meidute, Amisten, Stefan, Salehi, S Albert,, Lund University.   +8 more
core   +1 more source

Involvement of P2Y receptors in the differentiation of haematopoietic cells.

, 2003
The effects of extracellular nucleotides are mediated by multiple P2X ionotropic receptors and G protein-coupled P2Y receptors. These receptors are ubiquitous, but few physiological roles have been firmly identified.
Sak, Katrin, Boeynaems, Jean-Marie, Everaus, Hele   +2 more
core  

P2Y₁, P2Y₂, P2Y₄, and P2Y₆receptors are coupled to Rho and Rho kinase activation in vascular myocytes

, 2000
In the cardiovascular system, activation of ionotropic (P2X receptors) and metabotropic (P2Y receptors) P2 nucleotide receptors exerts potent and various responses including vasodilation, vasoconstriction, and vascular smooth muscle cell proliferation ...
Nathalie Vaillant, Alain-Pierre Gadeau, Hélène le Jeune, Chrystelle Cario-Toumaniantz, Claude Desgranges, Pierre Chardin, Gervaise Loirand, Vincent Sauzeau, Pierre Pacaud, Elizabeth Scalbert   +9 more
core   +1 more source

Role of P2Y Receptors in Platelet Extracellular Vesicle Release. [PDF]

Int J Mol Sci, 2020
Gąsecka A, Rogula S, Eyileten C, Postuła M, Jaguszewski MJ, Kochman J, Mazurek T, Nieuwland R, Filipiak KJ.   +8 more
europepmc   +1 more source

Overview of the pharmacology and physiological roles of P2Y receptors

, 2012
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet-dense granules), vesicular trafficking, or efflux through membrane channels.
Boeynaems, Jean-Marie, Bernard Robaye, Communi, Didier, Didier Communi, Robaye, Bernard, Jean‐Marie Boeynaems   +5 more
core   +1 more source

Distinct P2Y Receptors Mediate Extension and Retraction of Microglial Processes in Epileptic and Peritumoral Human Tissue. [PDF]

J Neurosci, 2020
Milior G, Morin-Brureau M, Chali F, Le Duigou C, Savary E, Huberfeld G, Rouach N, Pallud J, Capelle L, Navarro V, Mathon B, Clemenceau S, Miles R.   +12 more
europepmc   +1 more source

Reviewing the role of P2Y receptors in specific gastrointestinal cancers. [PDF]

Purinergic Signal, 2019
Bellefeuille SD, Molle CM, Gendron FP.
europepmc   +1 more source

Knowledge domain and evolutionary trends of P2Y receptors in cardiovascular diseases: a bibliometric and altmetric analysis. [PDF]

Front Pharmacol
Yang M, Chen X, Lie S, Li J, Chen X, Chen J, Zhang Z, Lu L, Zeng J.   +8 more
europepmc   +1 more source

Machine learning-aided search for ligands of P2Y₆ and other P2Y receptors. [PDF]

Purinergic Signal
Puhl AC, Lewicki SA, Gao ZG, Pramanik A, Makarov V, Ekins S, Jacobson KA.   +6 more
europepmc   +1 more source