Results 81 to 90 of about 688,584 (205)

Protective role of P2Y2 receptor against lung infection induced by pneumonia virus of mice. [PDF]

PLoS ONE, 2012
ATP released in the early inflammatory processes acts as a danger signal by binding to purinergic receptors expressed on immune cells. A major contribution of the P2Y(2) receptor of ATP/UTP to dendritic cell function and Th2 lymphocyte recruitment during
Gilles Vanderstocken, Els Van de Paar, Bernard Robaye, Larissa di Pietrantonio, Benjamin Bondue, Jean-Marie Boeynaems, Daniel Desmecht, Didier Communi   +7 more
doaj   +1 more source

G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
High‐altitude hypobaric hypoxia activates multiorgan GPCR signaling networks that regulate ventilatory responses, cerebral endothelial barrier integrity, erythropoiesis and red blood cell metabolism, pulmonary vascular remodeling, and cardiac adaptation. Dysregulated GPCR pathways contribute to acute and chronic high‐altitude diseases, while clinically
Qing Zhao, Changliang Liu, Lu Dai, Kun Zheng, Kun Liang, Chuanling Pan, Lianhua Liu, Ling Chen, Xuefei He, Hui Yan, Lei Chen, Huaping Zheng, Cheng Deng, Fengming Luo   +13 more
wiley   +1 more source

Purinergic Receptor P2Y2 Regulates Neurogenesis and Functional Recovery Following Spinal Cord Injury in Zebrafish

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Although purinergic P2Y2 receptor can regulate neural stem cell (NSC) proliferation and neurogenesis in mammals, it is downregulated following spinal cord injury (SCI). It was previously unknown whether this receptor regulates these processes in the more‐regenerative zebrafish model, where the contribution of these responses allows near‐complete ...
Isaac J. Sullivan, Eva E. Stefanova, Mavis C. Chinn, Thomas A. Burke, Bradley G. Fitzgerald, Matthew T. Sorbara, Terence J. Van Raay, Angela L. Scott   +7 more
wiley   +1 more source

The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues

, 2009
In the sympathetic nervous system, ATP is a co-transmitter and modulator of transmitter release, inhibiting noradrenaline release by acting on P2Y autoreceptors, but in peripheral tissues the subtypes involved have only scarcely been identified.
Sonia Fraga, Jorge Goncalves, Clara Quintas, Gloria Queiroz   +3 more
core   +1 more source

Beyond the surface: P2Y receptor downstream pathways, TLR crosstalk and therapeutic implications for infection and autoimmunity

Pharmacological Research
A successful immune response must effectively obtain pathogen clearance upon infection while preventing excessive collateral tissue damage. It is therefore essential to achieve a nuanced fine regulation of pro- and anti-inflammatory signals to ...
Lena Rueschpler, Sebastian Schloer
doaj   +1 more source

GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors

BMC Genomics, 2002
Background Based on sequence similarity, the superfamily of G protein-coupled receptors (GPRs) can be subdivided into several subfamilies, the members of which often share similar ligands.
Chica Schaller H, Kreienkamp Hans-Jürgen, Munck Antonia, Hellebrand Susanne, Wittenberger Timo, Hampe Wolfgang   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y(2) and P2Y(6) receptors on cardiomyocytes and release of UTP in man during myocardial infarction [Elektronisk resurs] [PDF]

, 2006
The aim of this study was to examine a possible role for extracellular pyrimidines as inotropic factors for the heart. First, nucleotide plasma levels were measured to evaluate whether UTP is released in patients with coronary heart disease.
Cedercrantz-Borna, Catharina,, Dou, Y, Erlinge, David,, Wang, Lingwei,, Wihlborg, Anna-Karin,, Lazarowski, E, Balogh, Johanna,, Joshi, BV, Lund University., Jacobson, KA, Arner, Anders,   +10 more
core   +2 more sources

Anterior Cingulate Cortex Astrocytes Regulate Chronic Itch and Comorbid Negative Emotional Disorders in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
ACC astrocytes are morphologically and functionally activated in DCP‐induced chronic itch. Chemogenetic activation of these astrocytes positively modulates the calcium activity of local CaMKII+ excitatory neurons and the release of D‐serine and ATP, and exerts anti‐pruritic, anxiolytic, and anti‐depressant effects.
Ze Fan, Xiaotong Shi, You Wu, Ningcan Ma, Ziyi Dai, Lisen Wang, Yushan Jin, Yuanyuan Zhu, Yiming Chen, Haopeng Zhang, Hui Zhang, Shengxi Wu, Jing Huang   +12 more
wiley   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, Volume 2, Issue 3, Page 334-351, September 2026.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source