Results 61 to 70 of about 688,584 (205)

GPR80/99, proposed to be the P2Y15 receptor activated by adenosine and AMP, is not a P2Y receptor [PDF]

Purinergic Signalling, 2004
The orphan receptor GPR80 (also called GPR99) was recently reported to be the P2Y(15) receptor activated by AMP and adenosine and coupled to increases in cyclic AMP accumulation and intracellular Ca(2+) mobilization (Inbe et al. J Biol Chem 2004; 279: 19790-9). However, the cell line (HEK293) used to carry out those studies endogenously expresses A(2A)
Qi, Ai-Dong, Harden, T. Kendall, Nicholas, Robert A.   +2 more
openaire   +2 more sources

Dual Effect of Nucleotides on P2Y Receptors [PDF]

IUBMB Life, 2000
The interaction of ADP, 2MeSADP, and ADPbetaS with the adenine nucleotide receptor P2Y1 in the hP2Y1-1321N1 cell line and of UDP with a receptor or receptors recognizing pyrimidine nucleotides in NG108-15 cells was studied over a wide range ofligand concentrations.
K, Sak, E A, Barnard, J, Järv
openaire   +2 more sources

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Pharmacological characterization of P2Y receptor subtypes – an update

, 2023
<jats:title>Abstract</jats:title><jats:p>P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y<jats:sub>1</jats:sub>, P2Y<jats:sub>2 ...
Ivar von Kügelgen, von Kügelgen, Ivar
core   +1 more source

Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Extracellular ATP performs multiple important functions via activation of P2 receptors on the cell surface. P2Y receptors play critical roles in ATP evoked response in human lung adenocarcinoma cells (A549 cells).
Xia Wang, Long Li, Ruijuan Guan, Danian Zhu, Nana Song, Linlin Shen   +5 more
doaj   +1 more source

The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism. [PDF]

PLoS ONE, 2012
ADP is an important physiological agonist that induces integrin activation and platelet aggregation through its receptors P2Y(1) (Gα(q)-coupled) and P2Y(12) (Gα(i)-coupled). P2Y(12) plays a critical role in platelet activation and thrombosis.
Binggang Xiang, Guoying Zhang, Hongmei Ren, Manjula Sunkara, Andrew J Morris, T Kent Gartner, Susan S Smyth, Zhenyu Li   +7 more
doaj   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 12, Page 1949-1964, December 2026.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Characterisation of canine P2X and P2Y receptors

, 2021
Purinergic signalling is an important biological process that utilises extracellular nucleotides to activate P2X and P2Y purinergic receptors. P2 receptors play a range of roles in human physiology and pathophysiology. Despite this, little is known about
Reece Andrew Sophocleous (20166279)
core   +1 more source

Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y₁₂ Receptor Antagonists

Molecules, 2019
Large inter-individual variation in platelet response to endogenous agonists and pharmacological agents, including resistance to antiplatelet therapy, prompts a search for novel platelet inhibitors and development new antithrombotic strategies.
Nina Wolska, Magdalena Boncler, Dawid Polak, Joanna Wzorek, Tomasz Przygodzki, Magdalena Gapinska, Cezary Watala, Marcin Rozalski   +7 more
doaj   +1 more source

Enteric Neurons and Glial Cells Are Partially Protected in P2X7 Receptor‐Deficient Mice With Ulcerative Colitis

Neurogastroenterology &Motility, Volume 38, Issue 11, November 2026.
P2X7R knockout mice efficacy. Chronic DSS‐induced colitis decreased the nitrergic and cholinergic neurons, β3‐tubulin–ir neurons, and GFAP‐ir and S100β glial cells in WT/DSS and KO/DSS groups. P2X7R‐ir cells decreased in WT/DSS animals, and NLRP3‐ir cells increased mostly in WT/DSS, indicating inflammasome activation.
Roberta Figueiroa Souza, Marcos Antônio Ferreira Caetano, Caroline Bures De Paulo, Patricia Castelucci   +3 more
wiley   +1 more source