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ATP-related purinergic signaling via P2Y12 contributes to airway epithelial barrier integrity. [PDF]
Tsuya K +9 more
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P2Y Receptors: In the Middle of the Road
Trends in Pharmacological Sciences, 2000info:eu-repo/semantics ...
Jean-Marc Herbert +2 more
exaly +4 more sources
Pharmacology and Structure of P2Y Receptors
Neuropharmacology, 2016P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y receptors are widely expressed and play important roles in physiology and pathophysiology.
Ivar von Kügelgen
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Molecular Pharmacology of P2Y Receptor Subtypes
Biochemical Pharmacology, 2021Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1 and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular adenine and uracil nucleotides. Eight mammalian P2Y receptor subtypes have been identified.
Ivar von Kügelgen
exaly +3 more sources
P2Y Receptors in Immune Response and Inflammation
Advances in Immunology, 2017Metabotropic pyrimidine and purine nucleotide receptors (P2Y receptors) are expressed in virtually all cells with implications in very diverse biological functions, including the well-established platelet aggregation (P2Y12), but also immune regulation and inflammation.
Torsten Schöneberg +2 more
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P2Y receptors in neuropathic pain
Pharmacology Biochemistry and Behavior, 2019This review summarizes and evaluates the relationship between neuropathic pain and P2Y receptors from inception to 2019. Purinergic receptors have been well studied in recent years using various molecular biological methods. The main research objective of this review is to determine the association of P2Y1, P2Y2, P2Y6, P2Y12 and P2Y13 receptors with ...
Xinge, Zhang, Guilin, Li
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Trends in Biochemical Sciences, 2000
Since the mediatory role of extracellular nucleotides was proposed in the early 1970s1xNomenclature and classification of purinoceptors. Fredholm, B.B. et al. Pharmacol. Rev. 1994; 46: 143–156PubMedSee all References1, nine nucleotide receptors belonging to the P2Y-receptor family have been cloned and expressed2xCloning of a human purinergic P2Y ...
K, Sak, A, Kreegipuu, J, Järv
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Since the mediatory role of extracellular nucleotides was proposed in the early 1970s1xNomenclature and classification of purinoceptors. Fredholm, B.B. et al. Pharmacol. Rev. 1994; 46: 143–156PubMedSee all References1, nine nucleotide receptors belonging to the P2Y-receptor family have been cloned and expressed2xCloning of a human purinergic P2Y ...
K, Sak, A, Kreegipuu, J, Järv
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Functions of neuronal P2Y receptors
Pflügers Archiv - European Journal of Physiology, 2006Within the last 15 years, at least eight different G protein-coupled nucleotide receptors, i.e., P2Y receptors, have been characterized by molecular means. While ionotropic P2X receptors are mainly involved in fast synaptic neurotransmission, P2Y receptors rather mediate slower neuromodulatory effects. This P2Y receptor-dependent neuromodulation relies
Simon, Hussl, Stefan, Boehm
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Molecular pharmacology of P2Y-receptors
Naunyn-Schmiedeberg's Archives of Pharmacology, 2000Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong to the superfamily of G-protein-coupled receptors. So far, the P2Y family is composed of eight cloned and functionally defined subtypes.
I, von Kügelgen, A, Wetter
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