Results 161 to 170 of about 688,584 (205)

Presynaptic Adenosine and P2Y Receptors

2008
Adenine-based purines, such as adenosine and ATP, are ubiquitous molecules that, in addition to their roles in metabolism, act as modulators of neurotransmitter release through activation of presynaptic P1 purinoceptors or adenosine receptors (activated by adenosine) and P2 receptors (activated by nucleotides).
Jorge, Gonçalves, Glória, Queiroz
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P2Y Receptors in Health and Disease

2011
The purine- and pyrimidine-sensitive P2Y receptors belong to the large group of G-protein-coupled receptors that are the target of approximately one-third of the pharmaceutical drugs used in the clinic today. It is therefore not unexpected that the P2Y receptors could be useful targets for drug development.
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Characteristics of the P2Y 11 nucleotide receptor - ligand binding characteristics and P2Y 11-P2Y 1 receptor [PDF]

, 2007
Purinergic receptors, nucleotides, P2Y, diastereoselectivity, potency, mutagenesis, ligand recognition, heterooligomerization, endocytosis, co-pulldownMagdeburg, Univ., Fak.
Ecke, Denise
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P2Y receptors

2000
info:eu-repo/semantics ...
Boeynaems, Jean-Marie, Communi, Didier, Suarez Gonzalez, Nathalie, Janssens, Rodolphe, Robaye, Bernard   +4 more
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Recombinant P2Y receptors: the UCL experience

Journal of the Autonomic Nervous System, 2000
The beginning of the last decade heralded three important and sequential developments in our understanding of cell-to-cell signalling by extracellular ATP via its cell surface receptors, the P2 purinoceptors. One major development in ATP signalling culminated in a timely review in 1991, when it was established in the clearest of terms that ATP ...
B F, King, A, Townsend-Nicholson
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The P2Y nucleotide receptors in the human genome

Acta Biologica Hungarica, 2003
Since the first identification of P2Y receptor sequences in 1993, it has quickly become apparent that this family of the G-protein coupled receptors is very diverse. Members of this receptor family are activated extra-cellularly by a wide variety of adenosine and uridine nucleotides including sugar-nucleotides.
Simon, J., Barnard, E. A.
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Cloning and Characterization of a Bovine P2Y Receptor ∮

Biochemical and Biophysical Research Communications, 1995
Using a chick P2Y1 receptor cDNA probe we have isolated a mammalian P2Y receptor clone from a bovine aortic endothelial cell library. The sequence has a high degree of similarity to the chick P2Y1 clone. When transfected into the Jurkat cell line, the cDNA conferred sensitivity to purinoceptor agonists.
D J, Henderson, D G, Elliot, G M, Smith, T E, Webb, I A, Dainty   +4 more
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Receptors | P2Y Receptors

2021
George R. Dubyak, Sarah C. Stainbrook
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Imagination and reality in the search for the P2Y receptors

Journal of the Autonomic Nervous System, 2000
A great body of evidence based on tissue and organ physiology and pharmacology led to the recognition, widespread by about 1990, that there must be cell membrane receptors for extracellular nucleotides to transduce their effects. This evidence was provided by the pioneering work of Geoffrey Burnstock and those who worked with him, or was developed by ...
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P2Y Receptors: Structure and Function

2001
Following the finding that nucleotides act as extracellular signalling molecules by interaction with cell surface transmembrane P2 receptors, it has now been recognised that this mode of regulation is widespread, exerting a ubiquitous influence on physiological function.
Boarder, M. R., Webb, T. E.
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