Results 211 to 220 of about 21,110 (244)
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Recombinant P2Y receptors: the UCL experience
Journal of the Autonomic Nervous System, 2000The beginning of the last decade heralded three important and sequential developments in our understanding of cell-to-cell signalling by extracellular ATP via its cell surface receptors, the P2 purinoceptors. One major development in ATP signalling culminated in a timely review in 1991, when it was established in the clearest of terms that ATP ...
B F, King, A, Townsend-Nicholson
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Presynaptic Adenosine and P2Y Receptors
2008Adenine-based purines, such as adenosine and ATP, are ubiquitous molecules that, in addition to their roles in metabolism, act as modulators of neurotransmitter release through activation of presynaptic P1 purinoceptors or adenosine receptors (activated by adenosine) and P2 receptors (activated by nucleotides).
Jorge, Gonçalves, Glória, Queiroz
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Pharmacology and structure of P2Y receptors
Neuropharmacology, 2016P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y receptors are widely expressed and play important roles in physiology and pathophysiology.
Ivar, von Kügelgen, Kristina, Hoffmann
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P2Y Receptors: Structure and Function
2001Following the finding that nucleotides act as extracellular signalling molecules by interaction with cell surface transmembrane P2 receptors, it has now been recognised that this mode of regulation is widespread, exerting a ubiquitous influence on physiological function.
M. R. Boarder, T. E. Webb
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P2Y Receptors in Health and Disease
2011The purine- and pyrimidine-sensitive P2Y receptors belong to the large group of G-protein-coupled receptors that are the target of approximately one-third of the pharmaceutical drugs used in the clinic today. It is therefore not unexpected that the P2Y receptors could be useful targets for drug development.
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P2Y receptor antagonists in thrombosis.
Current opinion in investigational drugs (London, England : 2000), 2005The dual role of P2Y1 and P2Y12 receptors in platelet aggregation by ADP has been firmly established, based on the action of selective inhibitors, gene targeting in mice and human genetic evidence. Both of these receptor subtypes constitute targets for antithrombotic agents, and compounds with a dual action might also be of interest.
Boeynaems, Jean-Marie +3 more
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