Results 21 to 30 of about 20,383 (265)
P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential. [PDF]
CNS Neurol Disord Drug Targets, 2012 P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Weisman GA, Woods LT, Erb L, Seye CI.
europepmc +3 more sources
Molecules, 2022 Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato +9 more
doaj +1 more source
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractBones are formed and remodeled by the coordinated actions of three key cell types. Osteoblasts, specialized connective tissue cells, deposit and then mineralize the collagenous bone matrix. Osteoclasts, which are derived from promonocytes, resorb mineralized matrix by excavating characteristic pits on bone surfaces.
Timothy R. Arnett, Isabel R. Orriss
openaire +2 more sources
Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]
, 1998 Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L. +13 more
core +3 more sources
P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. [PDF]
PLoS ONE, 2014 BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lacking.
Ricardo A Garcia +17 more
doaj +1 more source
Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization
Biomolecules, 2021 G-protein coupled receptors (GPCRs) are known to form homo- and hetero- oligomers which are considered critical to modulate their function. However, studying the existence and functional implication of these complexes is not straightforward as ...
Megan D. Joseph +4 more
doaj +1 more source
Immunolocalisation of P2Y receptors in the rat eye [PDF]
Purinergic Signalling, 2004 Nucleotides present an important role in ocular physiology which has been demonstrated by recent works that indicate their involvement in many ocular processes. P2Y are important among P2 receptors since they can control tear production, corneal wound healing, aqueous humour dynamics and retinal physiology.
Pintor Just, Jesús Jerónimo +5 more
openaire +5 more sources
Frontiers in Pharmacology, 2023 The P2Y receptors are responsible for the regulation of various physiological processes including neurotransmission and inflammatory responses. These receptors are also considered as novel potential therapeutic targets for prevention and treatment of ...
Sehrish Bano +6 more
doaj +1 more source
Drug-like antagonists of P2Y receptors — from lead identification to drug development [PDF]
, 2016 P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation.
Conroy, Sean +3 more
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ATP as a presynaptic modulator [PDF]
, 2000 © 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core +1 more source