Results 31 to 40 of about 20,383 (265)

Functional distribution of Ca²⁺-coupled P2 purinergic receptors among adrenergic and noradrenergic bovine adrenal chromaffin cells

BMC Neuroscience, 2007
Background Adrenal chromaffin cells mediate acute responses to stress through the release of epinephrine. Chromaffin cell function is regulated by several receptors, present both in adrenergic (AD) and noradrenergic (NA) cells.
Castro Enrique, Tomé Ângelo R, Santos Rosa M, Rosário Luís M   +3 more
doaj   +1 more source

P2X1 receptors and the endothelium

Memorias do Instituto Oswaldo Cruz, 2005
Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families.
LS Harrington, JA Mitchell
doaj   +1 more source

Purinergic receptor mediated calcium signalling in urothelial cells [PDF]

, 2019
Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the potential for ...
Brierley, Stuart M, Chess-Williams, Russell, Grundy, David, Grundy, Luke, Sellers, Donna J   +4 more
core   +3 more sources

P2Y receptors in the gastrointestinal epithelium [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractP2Y receptors are widely expressed in all gastrointestinal (GI) epithelia. Commonly, one epithelial tissue or cell expresses several P2Y receptors, which are located in both the apical and basolateral membranes. In almost all studied GI tissues, stimulation of P2Y receptors activates ion secretion, either that of NaCl, KCl, NaHCO3, or KHCO3. In
Larsen, Casper Kornbech, Leipziger, Jens Georg   +1 more
openaire   +3 more sources

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source

Apical membrane P2Y4 purinergic receptor controls K⁺ secretion by strial marginal cell epithelium

Cell Communication and Signaling, 2005
Background It was previously shown that K+ secretion by strial marginal cell epithelium is under the control of G-protein coupled receptors of the P2Y family in the apical membrane.
Scofield Margaret A, Scherer Elias Q, Lee Jun, Liu Jianzhong, Marcus Daniel C, Wangemann Philine   +5 more
doaj   +1 more source

Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]

, 2002
Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R., Braun, G. S., Horster, M. F., Huber, S. M., Tschop, J.   +4 more
core   +1 more source

Effects of 4(1H)-quinolinone derivative, a novel non-nucleotide allosteric purinergic P2Y 2 agonist, on cardiomyocytes in neonatal rats

Scientific Reports, 2017
Purinergic P2Y 2 receptors, G-protein coupled receptors that primarily couple with Gαq/11-proteins, are activated equipotently by adenosine-5′-triphosphate (ATP) and uridine-5′-triphosphate.
Kensuke Sakuma, Hideyuki Nakagawa, Tatsuo Oikawa, Masakuni Noda, Shota Ikeda   +4 more
doaj   +1 more source

P2Y receptors in lung inflammation [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractNucleotides, e.g., adenosine‐5′‐triphosphate (ATP), can be released into the extracellular space under acute or chronic inflammatory conditions and have been shown to serve as potent immunomodulators or danger signals involved in the initiation and maintenance of immune responses.
Tobias Müller, Marco Idzko
openaire   +2 more sources

Purinergic Signaling in Liver Pathophysiology

Frontiers in Endocrinology, 2021
Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
doaj   +1 more source