Results 41 to 50 of about 21,110 (244)
P2Y receptors in neurogenesis [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractG protein‐coupled P2Y receptors (Rs) regulate the function of embryonic and adult neural precursor cells (NPCs) which have the capacity to regenerate and give rise to cells belonging to all three major linages of the nervous system: neurons, oligodendrocytes and astrocytes.
Peter Illes +2 more
openaire +1 more source
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
core +1 more source
ATP as a presynaptic modulator [PDF]
, 2000 © 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core +1 more source
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractBones are formed and remodeled by the coordinated actions of three key cell types. Osteoblasts, specialized connective tissue cells, deposit and then mineralize the collagenous bone matrix. Osteoclasts, which are derived from promonocytes, resorb mineralized matrix by excavating characteristic pits on bone surfaces.
Isabel R. Orriss, Timothy R. Arnett
openaire +1 more source
ASN Neuro, 2012 Previous studies indicated that a ganglioside 9acGD3 (9-O-acetyl GD3) antibody [the J-Ab (Jones antibody)] reduces GCP (granule cell progenitor) migration in vitro and in vivo . We here investigated, using cerebellar explants of postnatal day (P) 6 mice,
Marcelo F Santiago, Eliana Scemes
doaj +1 more source
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. [PDF]
PLoS ONE, 2016 ATP and other nucleotides are released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y ...
Anael Viana Pinto Alberto +8 more
doaj +1 more source
P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]
, 2008 ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank +6 more
core +1 more source
Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]
, 2009 Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke +5 more
core +1 more source
Prostaglandin E2 Impairs P2Y2/P2Y4 Receptor Signaling in Cerebellar Astrocytes via EP3 Receptors
Frontiers in Pharmacology, 2017 Prostaglandin E2 (PGE2) is an important bioactive lipid that accumulates after tissue damage or inflammation due to the rapid expression of cyclooxygenase 2. PGE2 activates specific G-protein coupled EP receptors and it mediates pro- or anti-inflammatory
Lucía Paniagua-Herranz +7 more
doaj +1 more source
Transmission to interneurons is via slow excitatory synaptic potentials mediated by P2Y(1) receptors during descending inhibition in guinea-pig ileum. [PDF]
PLoS ONE, 2013 BACKGROUND: The nature of synaptic transmission at functionally distinct synapses in intestinal reflex pathways has not been fully identified. In this study, we investigated whether transmission between interneurons in the descending inhibitory pathway ...
Peter D J Thornton +3 more
doaj +1 more source