Results 121 to 130 of about 55,117 (228)

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Aerobic exercise facilitates p300 nuclear translocation via ADRB2-AMPKα signaling, leading to enhanced histone acetylation and mitigation of cognitive decline in APP/PS1 mice. [PDF]

Alzheimers Res Ther
Chai GS, Gao TL, Bi SG, Mao YM, Yang L, Wang FZ, Chen J, Wu JJ, Gong J, Geng S, Yuan JQ, Zhang KY, Yi HY, Lan ZC, Nie YJ, Yu H.   +15 more
europepmc   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [PDF]

Nat Commun
Tsutsui Y, Masui A, Konishi S, Tsujimura T, Iwasaki M, Yamamoto T, Gotoh S.   +6 more
europepmc   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Investigating event-related potential (ERP) deviations in clinical high-risk populations for psychosis: a systematic review and meta-analysis. [PDF]

BMC Psychiatry
Wei A, Gao R, Fan M, Luan P, Kong L, He X.   +5 more
europepmc   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Decoding P300 as a shared neural mechanism for oddball target detection and working memory updating. [PDF]

iScience
Yang W, Xiang S, Huang B.
europepmc   +1 more source

Central Abnormalities in Idiopathic Tinnitus With Mild Hearing Loss: Selective Attention and Preprocessing Dysfunction

Brain and Behavior, Volume 16, Issue 3, March 2026.
Idiopathic tinnitus and mild hearing loss may lead to selective attention and preprocessing dysfunction. ABSTRACT Objectives To verify the abnormal brain electrical activity of idiopathic tinnitus through auditory event‐related potentials and elucidate the impact of mild hearing loss.
Xingqian Shen, Hui Pan, Yingzhao Liu, Ziying Xu, Xiaoye Chen, Qin Liu, Kaijun Xia, Wen Xie, Linlin Wang, Bo Liu, Hongjun Xiao   +10 more
wiley   +1 more source

Trait self-responsibility modulates neural responses to near-miss loss: an ERP study. [PDF]

Front Hum Neurosci
Jin X, Yin H.
europepmc   +1 more source