Results 11 to 20 of about 55,117 (228)

p300 promotes proliferation, migration, and invasion via inducing epithelial-mesenchymal transition in non-small cell lung cancer cells

BMC Cancer, 2018
Background Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers.
Xue Hou, Run Gong, Jianhua Zhan, Ting Zhou, Yuxiang Ma, Yuanyuan Zhao, Yaxiong Zhang, Gang Chen, Zhonghan Zhang, Shuxiang Ma, Xi Chen, Fangfang Gao, Shaodong Hong, Fan Luo, Wenfeng Fang, Yunpeng Yang, Yan Huang, Likun Chen, Haoxian Yang, Li Zhang   +19 more
doaj   +1 more source

Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells

Frontiers in Immunology, 2021
The proprotein convertase enzyme FURIN promotes the proteolytic maturation of pro-proteins and thereby it serves as an important factor for maintaining cellular homeostasis.
Zsuzsanna Ortutay, Anna Grönholm, Melina Laitinen, Melinda Keresztes-Andrei, Ismail Hermelo, Marko Pesu, Marko Pesu   +6 more
doaj   +1 more source

Auditory event-related potential (P300) in patients with schizophrenia

Medical Journal of Babylon, 2021
Background: Schizophrenia is a psychiatric disorder characterized by multiple symptoms such as positive symptoms, negative symptoms, and cognitive symptoms. Cognitive deficit can be detected with specific neurophysiological tests.
Zahraa Tariq Hasson, Ali Fuad Al-Hashimi, Uday Khalid Al Qaisy   +2 more
doaj   +1 more source

P300 com estímulo verbal e não verbal em adultos normo-ouvintes P300 with verbal and nonverbal stimuli in normal hearing adults

Brazilian Journal of Otorhinolaryngology, 2011
O P300 é resultado da focalização da atenção a estímulos raros, dentre outros estímulos frequentes, e investiga a atenção e a memória recente, ambos dependentes da discriminação entre os estímulos, quer sejam verbais ou não verbais.
Camila Gonçalves Polo Massa, Camila Maia Rabelo, Carla Gentile Matas, Eliane Schochat, Alessandra Giannella Samelli   +4 more
doaj   +1 more source

Decreased expression of nuclear p300 is associated with disease progression and worse prognosis of melanoma patients.

PLoS ONE, 2013
BackgroundGenomic instability due to UV radiation is one of the leading causes for melanoma. Histone acetyltransferase p300 plays an indispensible role in DNA repair and maintenance of genomic integrity.
Anand Rotte, Madhuri Bhandaru, Yabin Cheng, Cecilia Sjoestroem, Magdalena Martinka, Gang Li   +5 more
doaj   +1 more source

CBP and p300 Jointly Maintain Neural Progenitor Viability but Play Unique Roles in the Differentiation of Neural Lineages

Cells, 2022
The paralogous lysine acetyltransferases 3 (KAT3), CBP and P300, play critical roles during neurodevelopment, but their specific roles in neural precursors maintenance and differentiation remain obscure.
Rocío González-Martínez, Angel Márquez-Galera, Beatriz Del Blanco, Jose P. López-Atalaya, Angel Barco, Eloísa Herrera   +5 more
doaj   +1 more source

p300/CBP and cancer [PDF]

Oncogene, 2004
p300 and cyclic AMP response element-binding protein (CBP) are adenoviral E1A-binding proteins involved in multiple cellular processes, and function as transcriptional co-factors and histone acetyltransferases. Germline mutation of CBP results in Rubinstein-Taybi syndrome, which is characterized by an increased predisposition to childhood malignancies.
Narayanan Gopalakrishna, Iyer, Hilal, Ozdag, Carlos, Caldas   +2 more
openaire   +2 more sources

Combined frontal and parietal P300 amplitudes indicate compensated cognitive processing across the lifespan

Frontiers in Aging Neuroscience, 2014
In the present study the frontal and parietal P300, elicited in an auditory oddball paradigm were investigated in a large sample of healthy participants (N=1,572), aged 6-87.
Rik evan Dinteren, Rik evan Dinteren, Martijn eArns, Martijn eArns, Marijtje L.A. eJongsma, Roy P.C. eKessels, Roy P.C. eKessels   +6 more
doaj   +1 more source

A comparison of cognitive functions in non-hypoxemic chronic obstructive pulmonary disease (COPD) patients and age-matched healthy volunteers using mini-mental state examination questionnaire and event-related potential, P300 analysis

Lung India, 2013
Objective: To assess sub-clinical cognitive dysfunctions in stable chronic obstructive pulmonary disease (COPD) patients having no hypoxemia vs. age-matched healthy volunteers using (i) an electrophysiological test: Auditory event related potential, P300
Prem Parkash Gupta, Sushma Sood, Atulya Atreja, Dipti Agarwal   +3 more
doaj   +1 more source

Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation

iScience, 2018
Summary: The transcriptional co-activator p300 is essential for p53 transactivation, although its precise role remains unclear. We report that p53 activates the acetyltransferase activity of p300 through the enhancement of p300 autoacetylation ...
Stephanie Kaypee, Smitha Asoka Sahadevan, Shilpa Patil, Piya Ghosh, Neeladri Sekhar Roy, Siddhartha Roy, Tapas K. Kundu   +6 more
doaj   +1 more source