Results 11 to 20 of about 154,769 (339)

Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification

Biomolecules, 2023
p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution of malignant ...
Qingmei Zeng, Kun Wang, Yongxiang Zhao, Qingzhi Ma, Zhinan Chen, Wan Huang   +5 more
doaj   +2 more sources

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. [PDF]

Molecular Neurodegeneration, 2020
BackgroundThe trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases ...
Arkin, Michelle, Boxer, Adam L, Chen, Xu, Cuervo, Ana Maria, Gan, Li, Gestwicki, Jason E, Karydas, Anna, Li, Yaqiao, Miller, Bruce L, Mok, Sue-Ann, Rojas, Julio C, Tang, Yinyan, Tsai, Richard M, Wang, Chao   +13 more
core   +2 more sources

Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents

Theranostics, 2022
The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their sequence homology and functional overlap and co-operation, are emerging as critical drivers of oncogenesis in the past several years.
Qingjuan Chen, Binhui Yang, Xiao-Chun Liu, Xu Dong Zhang, Lirong Zhang, Tao Liu   +5 more
semanticscholar   +1 more source

Targeting p300/CBP axis in lethal prostate cancer.

Cancer Discovery, 2021
Resistance to androgen receptor (AR) blockade in castration resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of the AR (AR-SV). Inhibitors of transcriptional co-activators that regulate AR
J. Welti, A. Sharp, N. Brooks, W. Yuan, C. McNair, Saswati N Chand, Abhijit Pal, I. Figueiredo, R. Riisnaes, B. Gurel, J. Rekowski, D. Bogdan, W. West, Barbara Young, M. Raja, A. Prosser, Jordan Lane, S. Thomson, J. Worthington, S. Onions, Jonathan Shannon, S. Paoletta, Richard Brown, D. Smyth, G. Harbottle, Veronica S. Gil, S. Miranda, M. Crespo, A. Ferreira, Rita Pereira, N. Tunariu, S. Carreira, A. Neeb, J. Ning, A. Swain, D. Taddei, Stand Up To Cancer-Pcf International Dream Team, M. Schiewer, K. Knudsen, N. Pegg, J. D. de Bono   +40 more
semanticscholar   +1 more source

CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos

EMBO Journal, 2022
Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal and paternal chromatin to acquire a permissive state for subsequent zygotic genome activation (ZGA).
Meng Wang, Zhiyuan Chen, Yi Zhang
semanticscholar   +1 more source

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity

Circulation, 2022
Background: Vascular smooth muscle cell (VSMC) phenotypic switching contributes to cardiovascular diseases. Epigenetic regulation is emerging as a key regulatory mechanism, with the methylcytosine dioxygenase TET2 acting as a master regulator of smooth ...
Raja Chakraborty, Allison C. Ostriker, Yi Xie, J. Dave, Ana Gamez-Mendez, P. Chatterjee, Yaw Abu, Jake Valentine, K. Lezon-Geyda, Daniel M. Greif, Vincent P. Schulz, P. Gallagher, W. Sessa, J. Hwa, K. Martin   +14 more
semanticscholar   +1 more source

p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/β‐catenin axis

Aging Cell, 2022
The transcription factor p300 is reportedly involved in age‐associated human diseases, including intervertebral disc degeneration (IDD). In this study, we investigate the potential role and pathophysiological mechanism of p300 in IDD.
Yingjie Hao, Z. Ren, Lei Yu, Guangduo Zhu, Panke Zhang, Jian Zhu, Shuyan Cao   +6 more
semanticscholar   +1 more source

CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers

Cancers, 2021
Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine acetyltransferases that serve as critical co-activators for transcription factors involved in diverse signaling pathways in cancer.
Aaron R Waddell, Haojie Huang, Daiqing Liao   +2 more
semanticscholar   +1 more source

The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress

Nature Aging, 2021
Organisms respond to mitochondrial stress by activating multiple defense pathways, including the mitochondrial unfolded protein response (UPRmt). However, how UPRmt regulators are orchestrated to transcriptionally activate stress responses remains ...
T. Y. Li, Maroun Bou Sleiman, Hao Li, Arwen W. Gao, Adrienne Mottis, Alexis M Bachmann, G. Alam, Xiaoxu Li, Ludger J. E. Goeminne, K. Schoonjans, J. Auwerx   +10 more
semanticscholar   +1 more source

Implementing Over 100 Command Codes for a High-Speed Hybrid Brain-Computer Interface Using Concurrent P300 and SSVEP Features

IEEE Transactions on Biomedical Engineering, 2020
Objective: Recently, electroencephalography (EEG)- based brain-computer interfaces (BCIs) have made tremendous progress in increasing communication speed.
Minpeng Xu, Jin Han, Yijun Wang, T. Jung, Dong Ming   +4 more
semanticscholar   +1 more source