Results 121 to 130 of about 2,488,628 (260)
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, EarlyView.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
Effects of Sleep Deprivation on Visual P300 [PDF]
, 2006 睡眠剥夺在日常生活工作中广泛存在,导致认知功能下降,其中警觉水平下降最为明显。实验采用Oddball范式辨别任务,研究了32名青年男性在不同睡眠剥夺条件(sleep deprivation,SD)下(SD21h、SD45h、SD69h、正常对照组)的事件相关电位(event-related potentials,ERPs)P300成分的变化。结果表明,随SD时间延长,P300波幅降低、潜伏期延长 ...
宋国萍, 苗丹民, 赵仑, 皇甫恩
core
Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4
Cell Proliferation, EarlyView.During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng +8 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic ...
Ping He +10 more
wiley +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
The FEBS Journal, EarlyView.Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
, 2008 Here we present a novel approach to detect P300 wave in single trial Visual Event Related Potential (VERP) signals using improved principal component analysis to enable a faster brain-computer interface (BCI) design.
Kiong, L.C. +5 more
core +1 more source
Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader +2 more
wiley +1 more source
People with Absolute Pitch Process Tones without Producing a P300
, 1984 The P300 is a positive-going component of the event-related potential. In subjects with absolute, or ``perfect,\u27\u27 pitch, the P300 elicited by the less frequent of two auditory probes is small or absent.
Donchin, Emanuel +2 more
core +1 more source