Results 131 to 140 of about 2,898,090 (272)

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

Journal of Diabetes Investigation, EarlyView.
MaR1 activates LGR6‐AMPK signaling to restore metabolic flexibility in diabetic hearts. Glycolytic recovery replenishes intracellular lactate to rescue protective protein lysine lactylation, which reactivates PINK1/Parkin‐mediated mitophagy to eliminate damaged mitochondria.
Bin Feng, Chao Chen, Lin Chen, Yuqiong Chen, Wenjun Mao, Peiran Yu, Hao Yu, Bimin Shi, Nannan Zhang   +8 more
wiley   +1 more source

Influence of Universal Adhesives With or Without Silane Compared to One‐Step and Two‐Step Silane Agents on Bond Strength to Lithium Disilicate

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To evaluate the microshear bond strength (μSBS) to lithium disilicate achieved with universal adhesives (with and without silane) compared with one‐step and two‐step silanes, immediately (IM) and after thermocycling (TC). Chemical interaction (CI) was also assessed.
Camilo Pulido, Michel Wendlinger, Gabriel David Cochinski, Camila Farias Monteles, Alessandro Dourado Loguercio   +4 more
wiley   +1 more source

Decision Making and the Brain: Neurologists' View [PDF]

The article reflects the fact, that concepts like decision making and free will have entered the field of cognitive neuroscience towards the end of 20th century. It gives an overview of brain structures involved in decision making and the concept of free
Milica Gregoric-Kramberger, Zvezdan Pirtosek, Dejan Georgiev   +2 more
core  

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Cis‐urocanic acid formation following far‐UVC exposure and associated signaling responses in keratinocytes

Photochemistry and Photobiology, EarlyView.
Far‐UVC (200–235 nm) has emerged as a safe and effective indoor disinfection tool, but effects on skin immunomodulation remain unclear. This study demonstrates that 222 nm far‐UVC converts trans‐urocanic acid (UCA) to its biologically active cis isomer at levels comparable with solar radiation. In keratinocytes, far‐UVC alone caused modest increases in
Lizzie Thomas, Gareth Hazell, Katarzyna Baczynska, Jinkang Zhang, Paul O'Mahoney   +4 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Acute exercise‐induced improvements in cognition: Role of cerebral blood flow and metabolism

Experimental Physiology, EarlyView.
Abstract Physical activity is widely recognized for its ability to promote brain health, with acute exercise transiently enhancing cognition and long‐term training attenuating cognitive decline. However, the mechanisms underlying these benefits remain incompletely understood.
Takeshi Hashimoto, Shigehiko Ogoh
wiley   +1 more source

Modulation of cerebral blood flow and cognition by hyperthermia and hypoxia: An electroencephalographic event‐related potentials perspective

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) is essential for sustaining neuronal metabolism and cognitive performance; however, the precise relationship between perfusion and cognition remains unclear. Although ageing and disease are associated with progressive declines in CBF and cognitive impairment, the acute effects of altered CBF under environmental ...
Hiroki Nakata, Shigehiko Ogoh, Manabu Shibasaki   +2 more
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source