Results 181 to 190 of about 281,509 (352)
Nuclear protein NP60 regulates p38 MAPK activity [PDF]
, 2006 The activation of p38 alpha is mediated by its upstream kinase and associated proteins. Here we identify a new nuclear protein, NP60, which regulates the activation of p38 alpha in response to sorbitol treatment. NP60 specifically binds to p38 alpha, but
韩家淮 +5 more
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BMEMat, EarlyView.This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao +3 more
wiley +1 more source
Mechanisms and functions of p38 MAPK signalling.
Biochemical Journal, 2010 A. Cuadrado, A. Nebreda
semanticscholar +1 more source
The primary structure of p38 gamma: A new member of p38 group of MAP kinases
, 1996 We have identified a third member of the p38 group of MAP kinase termed p38 gamma. The cDNA for this MAP kinase encodes an 367 amino acid polypeptide that is slightly greater than 60% identical to p38 and p38 beta.
Jiang, Y. +4 more
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Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation
BMEMat, EarlyView.Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh +5 more
wiley +1 more source
Biological Reviews, EarlyView.ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu +12 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT The role of artificial intelligence (AI) in achieving sustainability goals has garnered attention in academic literature. While AI has been argued to be crucial in addressing circularity challenges, organizations face challenges in configuring a business model.
Jian Wang +4 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Sustainable business practices are widely promoted in hospitality, yet a persistent gap persists between sustainability strategies and their implementation in daily operations. This study focuses on the sustainability strategy–implementation gap by examining how nonmanagerial employees, responsible for operational delivery, perceive and ...
Zivai Machaka Mare, Humeyra Dogru Dastan
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
大鼠脊髓小胶质细胞p38 MAPK介导rrIL-1β 诱导的机械痛敏
Zhongshan Daxue xuebao. Yixue kexue ban, 2010 【目的】 观察大鼠脊髓背角丝裂原活化蛋白激酶家族中的 p38(p38 MAPK)在坐骨神经周围给予重组大鼠白细胞介素-1β(rrIL-1β)引起的病理性疼痛中的作用65377;【方法】 通过检测大鼠50%机械刺激撤足阈值的变化观察坐骨神经周围给予rrIL-1β是否引起病理性疼痛,免疫组织化学观察给予rrIL-1β后1,7 d脊髓背角p38及小胶质细胞激活的情况65377;【结果】 0.1和 1 μg/L rrIL-1β可引起大鼠双侧后爪机械刺激痛阈下降,持续50 d左右65377;此外,1 μg/L ...
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