Results 221 to 230 of about 218,916 (306)

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Zonisamide attenuates morphine tolerance in association with reduced spinal TLR4/p38 MAPK signaling. [PDF]

Front Pharmacol
Gei LB, Liu YH, Guo H, Zhao X, Li LL, Zhang R, Cheng HX, Feng JJ, Zeng WA, Yan Y, E RQ, Chen DT.   +11 more
europepmc   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Correction: Transcriptomic profiling of autoimmune hepatitis identifies TRAT1 as an <i>in vitro</i> negative regulator of NK cell effector functions. [PDF]

Front Immunol
Gao J, Huo L, Zhong J, Cai J, Yu J, Li J, Jiang J, Hong C, Yao Y, Feng M.   +9 more
europepmc   +1 more source

TGF‐β Inhibition Attenuates Tau Accumulation and Neurodegeneration in Progressive Supranuclear Palsy Patient‐Derived Organoids

Movement Disorders, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a devastating 4‐repeat tauopathy with no approved disease‐modifying treatments. Recent evidence showed increased transforming growth factor‐β (TGF‐β) levels in PSP patient‐derived ventral midbrain organoids (vMOs) and serum neuronally derived exosomes. Objective This study investigated whether
Mariagrazia Talarico, Andrea Quattrone, Giorgia Lucia Benedetto, Raffaele Covello, Maurizio Martini, Valeria Zuccalà, Giovanni Cuda, Elvira Immacolata Parrotta, Aldo Quattrone   +8 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

The deubiquitinase CYLD inhibits thrombin-induced p38 MAPK-p65 NF-κB signaling and inflammatory cytokine production to suppress triple-negative breast cancer progression. [PDF]

J Biol Chem
Pimentel JM, Bosompra O, Trejo J.
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source