Results 211 to 220 of about 166,874 (259)

Benzimidazolone p38 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2004
The synthesis and in vitro p38 alpha activity of a novel series of benzimidazolone inhibitors is described. The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alpha in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors ...
Mark A, Dombroski   +17 more
openaire   +2 more sources

p38 activation and viral infection

Expert Reviews in Molecular Medicine, 2022
AbstractViruses completely rely on the energy and metabolic systems of host cells for life activities. Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no specific clinical vaccines or drugs against most viral infections. Therefore, understanding the molecular and cellular mechanisms of viral infections is
Luyao, Wang   +7 more
openaire   +2 more sources

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