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Benzimidazolone p38 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2004
The synthesis and in vitro p38 alpha activity of a novel series of benzimidazolone inhibitors is described. The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alpha in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors ...
Mark A, Dombroski   +17 more
openaire   +3 more sources

P38

Oral Diseases, 2005
Transferred to oral ...
openaire   +1 more source

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