Neuronal p38 MAPK Signaling Contributes to Cisplatin-Induced Peripheral Neuropathy [PDF]
AntioxidantsThis study investigates the role of p38 mitogen-activated protein kinase (MAPK) activation in dorsal root ganglion (DRG) neurons in the development and progression of chemotherapy-induced peripheral neuropathy (CIPN).
Yugal Goel +5 more
doaj +2 more sources
Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy [PDF]
EMBO Molecular MedicineSpinal muscular atrophy (SMA) is a neurodegenerative disease caused by ubiquitous deficiency in the SMN protein. The identification of disease modifiers is key to understanding pathogenic mechanisms and broadening the range of targets for developing SMA ...
Maria J Carlini +10 more
doaj +2 more sources
Evidence for the involvement of p38 MAPK activation in barnacle larval settlement. [PDF]
PLoS ONE, 2012 The barnacle Balanus ( = Amphibalanus) amphitrite is a major marine fouling animal. Understanding the molecular mechanism of larval settlement in this species is critical for anti-fouling research.
Li-Sheng He +6 more
doaj +1 more source
Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]
, 2020 BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai +10 more
core +1 more source
Design, crystal structure determination, molecular dynamic simulation and MMGBSA calculations of novel p38-alpha MAPK inhibitors for combating Alzheimer's disease [PDF]
, 2021 The hallmark of the Alzheimer's disease (AD) is the accumulation of aggregated, misfolded proteins. The cause for this accumulation is increased production of misfolded proteins and impaired clearance of them.
Gunasekaran, Krishnasamy +5 more
core +1 more source
Neural Plasticity, 2022 Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction.
Kun Hou, Zhi-cheng Xiao, Hai-Long Dai
doaj +1 more source
Frontiers in Oncology, 2022 Retinoblastoma (RB) is the most common intraocular malignancy in children. It has been previously reported that p38 MAPK is related to the pathogenesis of RB. Here we aim at investigating how p38 MAPK affected RB progression through mediating USP22/SIRT1/
Xiaoming Huang +10 more
doaj +1 more source
Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs. [PDF]
PLoS ONE, 2013 Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonary complications. Ozone reacts with the epithelial lining fluid and airway epithelium to produce reactive oxygen species and lipid peroxidation products ...
Kirsten C Verhein +4 more
doaj +1 more source
Biomedicines, 2023 High mortality in head and neck squamous cell carcinoma (HNSCC) is due to recurrence, metastasis, and radiochemotherapy (RCT) resistance. These phenomena are related to the tumor cell subpopulation undergoing partial epithelial to mesenchymal transition (
Julia Federspiel +3 more
doaj +1 more source
Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases
Scientific Reports, 2022 p38-MAPK is a stress-response kinase activated by hyperosmolarity. Here we interrogated the pathways involved. We show that p38-MAPK signaling is activated by hyperosmotic stimulation in various solutions, cell types and colonic organoids ...
Zetao Liu +5 more
doaj +1 more source