Results 181 to 190 of about 229,819 (298)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Integrated Identification of Macrophage NF-κB, p38 MAPK and AKT1 Signalling as Candidate Targets of Zerumbone in Experimental Periodontitis. [PDF]

Curr Issues Mol Biol
Long T, Dai F, Wang X, Hu Y, Jiang M, Cheng G, Yang K, Li L, Wang Z, Huang Y, Song L.   +10 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Coxsackievirus A6 infection exacerbates kidney injury in mice through the p38-MAPK pathway. [PDF]

Virol J
Sun T, Jiang W, Duan G, Li D, Ji W, Chen S, Yang H, Wang F, Chen S, Jin Y, Zhu P, Sun M.   +11 more
europepmc   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

LGMN regulates endothelial-to-mesenchymal transition via the p38 MAPK pathway to promote pulmonary fibrosis. [PDF]

Funct Integr Genomics
Zou Y, Zhang J, Chen D, Zhang Y, Fan J, Cai K.   +5 more
europepmc   +1 more source

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis

Phytotherapy Research, EarlyView.
BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo, Fansu Meng, Detang Li, Maciej Mazur, Alicia Marcelina Díaz García, Mulazim Hussain Asim, Zhong Chen, Yiqi Chen, Yixuan Lin, Zhenjiang Yang, Panpan Wang, Yu Cai   +11 more
wiley   +1 more source

Glucose-Dependent Cytotoxic Responses in Triple-Negative Breast Cancer: Experimental and Transcriptomic Evidence of Metabolic Context and p38 MAPK-Associated Modulation. [PDF]

Breast Cancer (Dove Med Press)
Rahman I, Henidi H, Alshibli A, Bin-Murdhi NS, Alqutaym MS, Alsheddi M, Alghamdi S, Bin Rayyis Snr AF, Alqahtani RA, Aljaddua LK, Mohammed AE.   +10 more
europepmc   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

FSCN1 Modulates Fatty Acid Metabolism and the Coordinated Activation of AKT/mTOR and p38 MAPK Pathways in Colorectal Cancer Cells. [PDF]

Oncol Res
Li Z, Yu X, Wu B, Zhang J, Ju X, Wang Y, Song J, Liu Q, Huang P, Ding Q, Wu Y.   +10 more
europepmc   +1 more source