Results 41 to 50 of about 205,636 (290)
Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]
, 2016 The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S. +3 more
core +1 more source
BMC Cancer, 2018 Background The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression of clock-controlled genes ...
Charles S. Goldsmith +6 more
doaj +1 more source
Inactivation of p38 MAPK during liver regeneration [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 There is increasing evidence that p38 MAPK, which is classified as a stress-activated kinase, also participates in cell cycle regulation, functioning as a suppressor of cell proliferation and tumorigenesis. We conducted a study of p38 MAPK phosphorylation during liver regeneration in mice to determine whether p38 MAPK activation or inactivation may ...
Jean S, Campbell +4 more
openaire +2 more sources
A role for p38 MAPK in the regulation of ciliary motion in a eukaryote
BMC Cell Biology, 2011 Background Motile cilia are essential to the survival and reproduction of many eukaryotes; they are responsible for powering swimming of protists and small multicellular organisms and drive fluids across respiratory and reproductive surfaces in mammals ...
Emery Aidan M +3 more
doaj +1 more source
A central role for p38 MAPK in the early transcriptional response to stress [PDF]
, 2010 The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in ...
Alan J Whitmarsh
core +3 more sources
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes [PDF]
, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
A Diaz +52 more
core +7 more sources
PLoS ONE, 2008 Cancer patients undergoing treatment with systemic cancer chemotherapy drugs often experience debilitating fatigue similar to sickness behavior, a normal response to infection or tissue damage caused by the production of the inflammatory cytokines IL ...
Collin R Elsea +3 more
doaj +1 more source
iScience, 2023 Summary: Anaplasma phagocytophilum modulates various cell signaling pathways in mammalian cells for its survival. In this study, we report that A. phagocytophilum modulates tick tryptophan pathway to activate arthropod p38 MAP kinase for the survival of ...
Prachi Namjoshi +3 more
doaj +1 more source
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]
, 2011 p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C. +6 more
core +3 more sources
p38 MAPK, Microglial Signaling, and Neuropathic Pain
Molecular Pain, 2007 Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to ...
Ji, Ru-Rong, Suter, Marc
openaire +4 more sources