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Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts
Vascular and Endovascular Surgery, 2008Objective: Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb. Methods: W-fb were isolated from venous ulcers and n-fb from the ipsilateral thigh.
Joseph D, Raffetto +3 more
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Structure-Activity Relationships of p38 Mitogen-Activated Protein Kinase Inhibitors
Mini-Reviews in Medicinal Chemistry, 2005Rheumatoid arthritis and other chronic inflammatory diseases constitute a major therapeutic challenge, usually not sufficiently met by the classical antiinflammatory medications. Recent research efforts provided new insights into the molecular basis of these pathologies and disclosed new opportunities for developing improved drugs directed to the ...
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p38 Mitogen Activated Protein Kinase as a Therapeutic Target for Alzheimer's Disease
Journal of Molecular Neuroscience, 2002The characteristic pathological hallmarks of Alzheimer's disease (AD) include neuritic plaques, neurofibrillary tangles, and inflammatory changes. Current therapies, such as molecules that target enhancing cholinergic activity, can improve cognitive function in the short term but, unfortunately, have no impact on progression of the disease.
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Assays for JNK and p38 Mitogen-Activated Protein Kinases
2000T, Sudo, M, Karin
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Diverse Mechanisms of Myocardial p38 Mitogen-Activated Protein Kinase Activation
Circulation Research, 2003Adrian Saurin +2 more
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The Many Paths to p38 Mitogen-Activated Protein Kinase Activation in the Immune System
Nature Reviews Immunology, 2006Jonathan D Ashwell
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