An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling [version 1; peer review: 2 approved] [PDF]
F1000Research, 2020 The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli.
Jiahuai Han, Jianfeng Wu, John Silke
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Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases. [PDF]
Mol Cell Biol, 2016 Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent
Dayalan Naidu S +13 more
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Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases [PDF]
Molecular and Cellular Biology, 2002 Nuclear factor of activated T cells (NFAT) is implicated in multiple biological processes, including cytokine gene expression, cardiac hypertrophy, and adipocyte differentiation. A conserved NFAT homology domain is identified in all NFAT members.
T. Yang +4 more
semanticscholar +4 more sources
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors [PDF]
Molecular and Cellular Biology, 1999 Mitogen-activated protein (MAP) kinase-mediated signalling to the nucleus is an important event in the conversion of extracellular signals into a cellular response.
Shen-hsi Yang +2 more
semanticscholar +5 more sources
Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. [PDF]
PLoS ONE, 2016 Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood.
Boon Siang Nicholas Tan +9 more
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The case for inhibiting p38 mitogen-activated protein kinase in heart failure [PDF]
Frontiers in Pharmacology, 2015 This minireview discusses the evidence that the inhibition of p38 mitogen-activated protein kinases (p38 MAPKs) maybe of therapeutic value in heart failure. Most previous experimental studies, as well as past and ongoing clinical trials, have focussed on
Pelin eArabacilar, Michael eMarber
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Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ [PDF]
Journal of Biological Chemistry, 1997 We have cloned and characterized a new member of the p38 group of mitogen-activated protein kinases here termed p38δ. Sequence comparisons revealed that p38δ is approximately 60% identical to the other three p38 isoforms but only 40–45% to the other ...
Yong Jiang +8 more
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p38 Mitogen-Activated Protein Kinases on the Body Surface – A Function for p38δ [PDF]
Journal of Investigative Dermatology, 2003 The p38 family of mitogen-activated protein kinases includes p38α (SAPK2a, CSBP), p38β (SAPK2b), p38δ (SAPK4), and p38γ (SAPK3/ERK6). p38α and p38β are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation ...
R. Eckert +5 more
semanticscholar +3 more sources
Role of p38 Mitogen-Activated Protein Kinases in Preconditioning [PDF]
Circulation Research, 2000 Preconditioning, the phenomenon whereby brief episodes of ischemia or pharmacological agents protect the myocardium against subsequent ischemic injury, consists of an early and a late phase.1 The early phase develops immediately and disappears within 1 ...
Peipei Ping, Elizabeth Murphy
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P38 mitogen-activated protein kinase and Parkinson’s disease [PDF]
Translational Neuroscience, 2018 AbstractParkinson’s disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson’s disease are not fully understood, considerable evidence suggests that neuro-inflammation, oxidative stress, mitochondrial dysfunction, cell proliferation, differentiation and apoptosis ...
Wenwen Zhong +5 more
openaire +3 more sources