Cooperation of p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways during Granulocyte Colony-stimulating Factor-induced Hemopoietic Cell Proliferation [PDF]
, 1999 Oliver Rausch, Christopher J. Marshall
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DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy
Aging Cell, EarlyView.In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding +8 more
wiley +1 more source
Rhubarb and Astragalus Capsule Attenuates Renal Interstitial Fibrosis in Rats with Unilateral Ureteral Obstruction by Alleviating Apoptosis through Regulating Transforming Growth Factor beta1 (TGF-β1)/p38 Mitogen-Activated Protein Kinases (p38 MAPK) Pathway. [PDF]
Med Sci Monit, 2020 Zeng X +8 more
europepmc +1 more source
How to use luspatercept and erythropoiesis‐stimulating agents in low‐risk myelodysplastic syndrome
British Journal of Haematology, EarlyView.Summary Anaemia is the most common cytopenia in myelodysplastic syndrome (MDS), significantly impacting quality of life and morbidity. Erythropoiesis‐stimulating agents (ESAs) are the first‐line treatment for anaemia in lower risk (LR)‐MDS. The European Medicines Agency (EMA) approved epoetin alpha for LR‐MDS‐related anaemia in 2017, based on evidence ...
Valeria Santini, Angela Consagra
wiley +1 more source
Activation of p38 Mitogen-Activated Protein Kinase by Oxidized LDL in Vascular Smooth Muscle Cells [PDF]
, 1999 Qing Jing +6 more
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Microbiology and Molecular Biology Reviews, 2004 Philippe P Roux, J. Blenis
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British Journal of Pharmacology, EarlyView.Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou +4 more
wiley +1 more source
LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinases⃞
Journal of Lipid Research, 2009 Intracellular signals elicited by LDLs are likely to play a role in the pathogenesis associated with increased LDL blood levels. We have previously determined that LDL stimulation of human skin fibroblasts, used as a model system for adventitial ...
Natasa Bulat +2 more
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Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. [PDF]
, 1996 Sen Jiang +5 more
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Opioid receptors in cardiovascular function
British Journal of Pharmacology, EarlyView.Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari +4 more
wiley +1 more source