Results 241 to 250 of about 177,903 (366)

Stimulation of p38 Mitogen-activated Protein Kinase Is an Early Regulatory Event for the Cadmium-induced Apoptosis in Human Promonocytic Cells [PDF]

open access: hybrid, 2000
Alba Galán   +6 more
openalex   +1 more source

Ferulic acid: extraction, estimation, bioactivity and applications for human health and food

open access: yesJournal of the Science of Food and Agriculture, Volume 105, Issue 8, Page 4168-4177, June 2025.
Abstract Ferulic acid ((E)‐3‐(4‐hydroxy‐3‐methoxy‐phenyl) prop‐2‐enoic acid) is a derivative of caffeic acid found in most plants. This abundant phenolic compound exhibits significant antioxidant capacity and a broad spectrum of therapeutic effects, including anti‐inflammatory, antimicrobial, anticancer, antidiabetic, cardiovascular and neuroprotective
Mukul Kumar   +13 more
wiley   +1 more source

The Role of Adipokines in Spinal Disease: A Narrative Review

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
Adipokines, bioactive molecules secreted by adipose tissue, play a key role in both physiological regulation and disease pathogenesis. While their involvement in various organ systems is well documented, their role in spinal pathology remains underexplored.
Jake M. McDonnell   +3 more
wiley   +1 more source

p38 Mitogen-activated Protein Kinase Regulates a Novel, Caspase-independent Pathway for the Mitochondrial Cytochromec Release in Ultraviolet B Radiation-induced Apoptosis [PDF]

open access: hybrid, 2000
Zerihun Assefa   +8 more
openalex   +1 more source

Antioxidant Natural Plant Constituents for Diabetic Wound Repair

open access: yesMedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Antioxidant natural plant constituents promote diabetic wound repair by ameliorating oxidative stress, inhibiting inflammatory responses, and promoting tissue regeneration. ABSTRACT Diabetes mellitus is a prevalent metabolic disorder characterized by a prolonged hyperglycemic state, which can result in complications affecting multiple organ systems ...
Lele Meng   +3 more
wiley   +1 more source

Role of p38 Mitogen-Activated Protein Kinase in Rhinovirus-Induced Cytokine Production by Bronchial Epithelial Cells [PDF]

open access: bronze, 2000
Sandra D. Griego   +4 more
openalex   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

open access: yesMedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu   +7 more
wiley   +1 more source

Colo‐Protective Effects of Pentoxifylline Alone or in Combination With Mesalamine in Colitis Through Sphingosine Kinase 1/Sphingosine 1 Phosphate, and Zonula Occuldin 1 Pathways: New Molecular Approach

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Multiple signaling pathways have been implicated in the pathogenesis of ulcerative colitis (UC), including Sphingosine Kinase 1 (SPHK)/Sphingosine‐1‐Phosphate (S1P), AMP‐activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/NLR family pyrin domain‐containing 3 (NLRP3), zonula occludens‐1 (ZO‐1), and signal transducer and ...
Fatemah A. Alherz   +18 more
wiley   +1 more source

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