The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response. [PDF]
PLoS ONE, 2011 Adenoviral vectors (AdV) activate multiple signaling pathways associated with innate immune responses, including mitogen-activated protein kinases (MAPKs).
Jeffrey S Smith +5 more
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Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. [PDF]
, 2015 BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens.
Aguirre, Alejandro +13 more
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The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution [PDF]
Proceedings of the National Academy of Sciences, 1997 The structure of mitogen-activated protein (MAP) kinase p38 has been solved at 2.1-Å to an R factor of 21.0%, making p38 the second low activity MAP kinase solved to date. Although p38 is topologically similar to the MAP kinase ERK2, the phosphorylation Lip (a regulatory loop near the active site) adopts a different
Elizabeth J. Goldsmith +5 more
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Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]
, 2006 Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Bogoyevitch +13 more
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The p38/MK2 Axis in Monocytes of Fibromyalgia Syndrome Patients: An Explorative Study
Medicina, 2021 Background and Objectives: The aetiology and pathomechanism of fibromyalgia syndrome 12 (FMS) as one of chronic pain syndromes still need to be further elucidated.
Boya Nugraha +4 more
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p38 Mitogen-activated Protein Kinase Regulates Oscillation of Chick Pineal Circadian Clock [PDF]
, 2003 Extracellular signal-regulated kinase (ERK) and p38 are members of the mitogen-activated protein kinase (MAPK) family, and in some cases these kinases serve for closely related cellular functions within a cell. In a wide range of animal clock structures,
Fukada, Yoshitaka +4 more
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p38 Mitogen-Activated Protein Kinase and Hematologic Malignancies
Archives of Pathology & Laboratory Medicine, 2009 Abstract Context.—p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in responses ranging from apoptosis to cell cycle, induction of expression of cytokine genes, and differentiation. This plethora of activators conveys the complexity of the p38 pathway.
Yongdong Feng +2 more
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The p38 Mitogen-Activated Protein Kinase Is Involved in Associative Learning in Rabbits [PDF]
The Journal of Neuroscience, 2001 This study examined the role of the mitogen-activated protein kinase (MAPK) family during acquisition of the rabbit's classically conditioned eye-blink response. Eye-blink conditioning produced a significant, bilateral activation of both extracellular signal-regulated protein kinases (ERKs) and p38 MAPK in the anterior cerebellar vermis. There was also
Anthony G. Romano +4 more
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c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core +1 more source
Circulation Research, 1998 The best-characterized subfamilies of the mitogen-activated protein kinase (MAPK) superfamily are the extracellularly responsive kinases (ERKs) and the two “stress-responsive” MAPK subfamilies, namely, the c-Jun N-terminal kinases (JNKs) and the p38 ...
P. Sugden, A. Clerk
semanticscholar +1 more source