Results 31 to 40 of about 183,974 (371)

Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Mediators of Inflammation, 2014
Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many ...
Yanyan Yang, Seung Cheol Kim, Tao Yu, Young-Su Yi, Man Hee Rhee, Gi-Ho Sung, Byong Chul Yoo, Jae Youl Cho   +7 more
doaj   +1 more source

Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release

Journal of Ginseng Research, 2019
Background: Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic ...
Jung-Hae Shin, Hyuk-Woo Kwon, Man Hee Rhee, Hwa-Jin Park   +3 more
doaj   +1 more source

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]

, 2010
The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core   +1 more source

Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK during Toxoplasma gondii invasion

Parasite, 2003
Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T.
Valère A., Garnotel R., Villena I., Guenounou M., Pinon J.M., Aubert D.   +5 more
doaj   +1 more source

The case for inhibiting p38 mitogen-activated protein kinase in heart failure

Frontiers in Pharmacology, 2015
This minireview discusses the evidence that the inhibition of p38 mitogen-activated protein kinases (p38 MAPKs) maybe of therapeutic value in heart failure. Most previous experimental studies, as well as past and ongoing clinical trials, have focussed on
Pelin eArabacilar, Michael eMarber
doaj   +1 more source

Group V Phospholipase A2 Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A2 [PDF]

, 2002
We reported previously that exogenously added human group V phospholipase A2 (hVPLA2) could elicit leukotriene B4 (LTB4) biosynthesis in human neutrophils (Han, S. K., Kim, K. P., Koduri, R., Bittova, L., Munoz, N. M., Leff, A. R., Wilton, D. C., Gelb, M.
Cho, Wonhwa, Han, Sang Kyou, Kim, Kwang Pyo, Kim, Young Jun, Leff, Alan R., Munoz, Nilda M., Sano, Hiroyuki, Zhu, Xiangdong   +7 more
core   +1 more source

Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor.

Journal of Immunology, 1996
B cell antigen receptor (BCR)-induced apoptosis in the WEHI-231 B lymphoma cell line can be prevented by engaging CD40. We have used this cell line to investigate the role of mitogen-activated protein (MAP) kinases in integrating BCR and CD40 signaling ...
Claire L. Sutherland, A. Heath, S. Pelech, P. Young, M. Gold   +4 more
semanticscholar   +1 more source

Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis [PDF]

Journal of Allergy and Clinical Immunology, 2019
Psoriasis is a chronic inflammatory skin disease characterized by IL-17-mediated immune responses. p38 is known to be highly activated in the psoriatic epidermis; however, whether p38 is involved in the development of psoriasis is unclear.We sought to demonstrate that activation of p38 mitogen-activated protein kinase is sufficient to induce psoriatic ...
Kenji, Sakurai, Teruki, Dainichi, Sandra, Garcet, Soken, Tsuchiya, Yosuke, Yamamoto, Akihiko, Kitoh, Tetsuya, Honda, Takashi, Nomura, Gyohei, Egawa, Atsushi, Otsuka, Saeko, Nakajima, Reiko, Matsumoto, Yuri, Nakano, Masayuki, Otsuka, Yoichiro, Iwakura, Yenkel, Grinberg-Bleyer, Sankar, Ghosh, Yukihiko, Sugimoto, Emma, Guttman-Yassky, James G, Krueger, Kenji, Kabashima   +20 more
openaire   +2 more sources

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source

Polygonatum sibiricum polysaccharide potentially attenuates diabetic retinal injury in a diabetic rat model

Journal of Diabetes Investigation, 2019
Aims/Introduction To investigate the protective effect of Polygonatum sibiricum polysaccharide (PSP) on the retina in diabetic rats. Materials and Methods A total of 120 Sprague–Dawley rats were randomly divided into blank control, control model (meaning
Yi Wang, Changjun Lan, Xuan Liao, Di Chen, Wengang Song, Qiuling Zhang   +5 more
doaj   +1 more source