Results 51 to 60 of about 4,400,135 (194)

Analyzing the role of p38 mitogen activated protein kinases and their effectors on mouse blastocyst maturation

, 2021
Bachelor's thesis demonstrates the role of p38 mitogen activated protein kinases and their effectors on mouse blastocyst ...
HAUSEROVÁ, Andrea
core  

p38 Mitogen-Activated Protein Kinase Contributes to Angiotensin II-Stimulated Migration of Rat Aortic Smooth Muscle Cells

Journal of Pharmacological Sciences, 2007
In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic ...
Hwan Myung Lee, Chang-Kwon Lee, So Hee Lee, Hui Yul Roh, Young Min Bae, Kyung-Yung Lee, Jaegeun Lim, Pyo-Jam Park, Tae-Kyu Park, Yun Lyul Lee, Kyung-Jong Won, Bokyung Kim   +11 more
doaj   +1 more source

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

PLOS ONE, 2015
Gaucher's disease is caused by defects in acid β-glucosidase 1 (GBA1) and has been also proposed as an inflammatory disease. GBA1 cleaves glucosylceramide to form ceramide, an established bioactive lipid, and defects in GBA1 lead to aberrant accumulation in glucosylceramide and insufficient formation of ceramide. We investigated if the pro-inflammatory
Kazuyuki Kitatani, Masayuki Wada, David Perry, Toshinori Usui, Ying Sun, Lina M Obeid, Nobuo Yaegashi, Gregory A Grabowski, Yusuf A Hannun   +8 more
openaire   +4 more sources

Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways

Genes and Diseases, 2022
Although there are many therapeutic strategies such as surgery and chemotherapy, the prognosis of osteosarcoma (OS) is still far from being satisfactory. It is urgent to develop more effective, tolerable and safe drugs for the treatment of OS.
Chunmei Yang, Lulu Zhang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yanran Huang, Xiaoji Luo, Jinyong Luo   +9 more
doaj   +1 more source

Molecular Cloning and Characterization of aDrosophila p38 Mitogen-activated Protein Kinase [PDF]

Journal of Biological Chemistry, 1998
A mitogen-activated protein kinase (MAPK) has been cloned and sequenced from a Drosophila neoplasmic l(2)mbn cell line. The cDNA sequence analysis showed that this Drosophila kinase is a homologue of mammalian p38 MAPK and the yeast HOG1 gene and thus was referred to as Dp38.
S J, Han, K Y, Choi, P T, Brey, W J, Lee
openaire   +2 more sources

Outer Membrane Protein 25 of Brucella Activates Mitogen-Activated Protein Kinase Signal Pathway in Human Trophoblast Cells

Frontiers in Veterinary Science, 2017
Outer membrane protein 25 (OMP25), a virulence factor from Brucella, plays an important role in maintaining the structural stability of Brucella. Mitogen-activated protein kinase (MAPK) signal pathway widely exists in eukaryotic cells.
Jing Zhang, Yu Zhang, Zhiqiang Li, Jing Liu, Xuehua Shao, Changxin Wu, Yong Wang, Kaisheng Wang, Tiansen Li, Laizhen Liu, Chuangfu Chen, Hui Zhang   +11 more
doaj   +1 more source

Akt2, a Novel Functional Link between p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Myogenesis [PDF]

, 2004
Activation of either the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt or the p38 mitogen-activated protein kinase (MAPK) signaling pathways accelerates myogenesis but only when the reciprocal pathway is functional. We therefore examined the hypothesis
Holding, C., Pell, J.M., González, I., Laura J. Cobb, Dervis A. M. Salih, Gyanendra Tripathi, Lovett, F., Cobb, L.J., Cathy Holding, Emma J. Carter, Fiona A. Lovett, Jennifer M Pell, Salih, D.A., Carter, E.J., Tripathi, G., Ivelisse Gonzalez   +15 more
core   +1 more source

Stress and Vascular Responses: Mitogen-Activated Protein Kinases and Activator Protein-1 as Promising Therapeutic Targets of Vascular Remodeling

Journal of Pharmacological Sciences, 2003
Mitogen-activated protein kinases (MAP kinases), including extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38, play a central role in cellular responses by various stress stimuli such as cell proliferation, apoptosis ...
Shokei Kim, Hiroshi Iwao
doaj   +1 more source

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

, 1997
Mitogen-activated protein (MAP) kinases bind tightly to many of their physiologically relevant substrates. We have identified a new subfamily of murine serine/threonine kinases, whose members, MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, bind tightly
Waskiewicz, Andrew J., Cooper, Jonathan A., Flynn, Andrea, Proud, Christopher G.   +3 more
core   +1 more source

Untersuchungen zur Regulierung und Funktion der Mitogen-aktivierten Proteinkinase ERK5 = Regulation and Function of the Mitogen-activated Protein Kinase ERK5 [PDF]

, 2003
Mitogen activated protein kinases (MAPKs) are found in all eukaryotic cells and represent crucial elements in the signal transduction from the plasma membrane to the nucleus.
Buschbeck, Marcus
core