Results 71 to 80 of about 4,400,135 (194)

The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation

Journal of Ginseng Research, 2015
Background: Korean Red Ginseng has been used as a traditional oriental medicine to treat illness and to promote health for several thousand years in Eastern Asia. It is widely accepted that ginseng saponins, ginsenosides, are the major active ingredients
Bo Ra Jeon, Su Jung Kim, Seung Bok Hong, Hwa-Jin Park, Jae Youl Cho, Man Hee Rhee   +5 more
doaj   +1 more source

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A., Olajide, Olumayokun A.; id_orcid   +7 more
core   +1 more source

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

Toxins, 2016
Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2.
Dakshina M. Jandhyala, John Wong, Nicholas J. Mantis, Bruce E. Magun, John M. Leong, Cheleste M. Thorpe   +5 more
doaj   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S, Bouloux, PM, Turnbull, Jeremy, Turnbull, J, Hu, Youli, Kim, SH, Kim, Soo-Hyun, Schofield, Jonathan, Winyard, P, Winyard, Paul, Vannelli, GB, Bouloux, Pierre-Marc, Gonzalez-Martinez, D, Hu, YL, Schofield, J, Vannelli, Gabriella Barbara, González-Martínez, David, Guimond, Scott   +17 more
core   +1 more source

LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinases⃞

Journal of Lipid Research, 2009
Intracellular signals elicited by LDLs are likely to play a role in the pathogenesis associated with increased LDL blood levels. We have previously determined that LDL stimulation of human skin fibroblasts, used as a model system for adventitial ...
Natasa Bulat, Gérard Waeber, Christian Widmann   +2 more
doaj   +1 more source

Neuroprotective Effects of Tetrahydrocurcumin against Glutamate-Induced Oxidative Stress in Hippocampal HT22 Cells

Molecules, 2019
In the central nervous system, glutamate is a major excitable neurotransmitter responsible for many cellular functions. However, excessive levels of glutamate induce neuronal cell death via oxidative stress during acute brain injuries as well as chronic ...
Chang-Hyun Park, Ji Hoon Song, Su-Nam Kim, Ji Hwan Lee, Hae-Jeung Lee, Ki Sung Kang, Hyung-Ho Lim   +6 more
doaj   +1 more source

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

, 2008
The cellular response to treatment with proinflammatory cytokines or exposure to environmental stress is mediated, in part, by the p38 group of mitogen-activated protein (MAP) kinases. We report the molecular cloning of a novel isoform of p38 MAP kinase,
Davis, Roger J., Enslen, Herve, Raingeaud, Joel   +2 more
core   +1 more source

Hyperthermia-mediated cell death via deregulation of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase signaling

Frontiers in Cell Death
Hyperthermia is a promising anticancer treatment that induces heat stress, thereby stimulating various signal transduction pathways to maintain cellular homeostasis.
Atsushi Enomoto, Takemichi Fukasawa, Takemichi Fukasawa, Ayumi Yoshizaki, Ayumi Yoshizaki   +4 more
doaj   +1 more source

Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-Activated Protein Kinases

Journal of Pharmacological Sciences, 2003
Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective.
Masanori Yoshizumi, Jun-ichi Abe, Koichiro Tsuchiya, Bradford C. Berk, Toshiaki Tamaki   +4 more
doaj   +1 more source

Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori

, 1999
The aim of this study was to determine whether Helicobacter pylori activates mitogen-activated protein (MAP) kinases in gastric epithelial cells. Infection of AGS cells with an H.
Keates, Andrew C., Warny, Michel, Keates, Sarah, Murray, Paul G., Kelly, Ciaran P., Peek, Richard M., Michel Warny, Andrew C. Keates, Paul G. Murray, Ciarán P. Kelly, Richard M. Peek, Sarah Keates   +11 more
core   +1 more source