Results 81 to 90 of about 4,400,135 (194)

Coxiella burnetii lipopolysaccharide blocks p38α-MAPK activation through the disruption of TLR-2 and TLR-4 association

Frontiers in Cellular and Infection Microbiology, 2015
To survive in macrophages, Coxiella burnetii hijacks the activation pathway of macrophages. Recently, we have demonstrated that C. burnetii, via its lipopolysaccharide (LPS), avoids the activation of p38α-MAPK through an antagonistic engagement of Toll ...
Filippo eConti, Nicolas eBoucherit, Veronica eBaldassarre, Virginie eTrouplin, Giovanna eMottola, Rudolf eToman, Jean-louis eMege, Eric eGhigo   +7 more
doaj   +1 more source

Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling

, 2012
Cellular responses require the activation of intracellular signal transduction pathways, particularly the activation of protein kinases. Mitogen-activated protein kinases (MAPKs) are responsible for a diverse range of physiological processes in cells ...
Lindsay Brown, Alam, Md. Ashraful, Alam, Md Ashraful, Uddin, Shaikh Jamal, Shaikh Jamal Uddin, Brown, Lindsay, Uddin, Shaikh, Md Ashraful Alam   +7 more
core   +1 more source

p38 Mitogen-activated protein kinase (p38 MAPK; MAPK14) [PDF]

Science-Business eXchange, 2012
  +6 more sources

Major Differences in Hypoxia Tolerance and P38 Regulation Among Different Renal Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mitogen-activated protein kinases (MAPKs) are involved in the cellular response to hypoxia and their dysregulation may contribute to the progression and pathology of diverse human renal diseases.
Qianqian Shi, Jian Shi, Fengbao Luo, Guanglai Song, Xiaozhou He, Ying Xia   +5 more
doaj   +1 more source

Revisiting p38 Mitogen-Activated Protein Kinases (MAPK) in Inflammatory Arthritis: A Narrative of the Emergence of MAPK-Activated Protein Kinase Inhibitors (MK2i). [PDF]

Pharmaceuticals (Basel), 2023
Ganguly P, Macleod T, Wong C, Harland M, McGonagle D.   +4 more
europepmc   +1 more source

Inhibition of p38 mitogen-activated protein kinases may attenuate scar proliferation after cleft lip surgery in rabbits via Smads signaling pathway. [PDF]

Eur J Med Res, 2022
Ding Q, Yue J, Xue LF, Xu YX, Xiao WL.
europepmc   +1 more source

Arctigenin attenuates paraquat-induced human lung epithelial A549 cell injury by suppressing ROS/p38 mitogen-activated protein kinases-mediated apoptosis. [PDF]

World J Emerg Med, 2022
Liu C, Sun ZR, Wang MM, Yang ZZ, Zhang W, Ren Y, Han XQ, Liu R, Li Q, Nie SN.   +9 more
europepmc   +1 more source

Stress-Activated Protein Kinases in Intervertebral Disc Degeneration: Unraveling the Impact of JNK and p38 MAPK

Biomolecules
Intervertebral disc degeneration (IDD) is a major cause of lower back pain. The pathophysiological development of IDD is closely related to the stimulation of various stressors, including proinflammatory cytokines, abnormal mechanical stress, oxidative ...
Lei Li, Guangzhi Zhang, Zhili Yang, Xuewen Kang   +3 more
doaj   +1 more source

p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage

Scientific Reports, 2017
XRCC1 is a scaffold protein involved in base excision repair and single strand break repair. It is a phosphoprotein that contains more than 45 phosphorylation sites, however only a few of these have been characterized and connected to specific kinases ...
Mirta Mittelstedt Leal de Sousa, Karine Øian Bjørås, Audun Hanssen-Bauer, Karin Solvang-Garten, Marit Otterlei   +4 more
doaj   +1 more source

Morphine Postconditioning Protects against Reperfusion Injury via Inhibiting JNK/p38 MAPK and Mitochondrial Permeability Transition Pores Signaling Pathways

Cellular Physiology and Biochemistry, 2016
Background: The purpose of this study was to determine whether c-jun NH2 amino-terminal kinases (JNK) and p38 mitogen-activated protein kinases (MAPK) were involved in morphine postconditioning (MpostC).
Zuolei Chen, Xuewei Zhang, Yingzhi Liu, Zhongkai Liu   +3 more
doaj   +1 more source