Results 61 to 70 of about 4,400,135 (194)

Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells. [PDF]

PLoS ONE, 2014
We previously reported that bupivacaine induces reactive oxygen species (ROS) generation, p38 mitogen-activated protein kinase (MAPK) activation and nuclear factor-kappa B activation, resulting in an increase in expression of WD repeat-containing protein
Lei Huang, Fumio Kondo, Masahiko Gosho, Guo-Gang Feng, Misako Harato, Zhong-yuan Xia, Naohisa Ishikawa, Yoshihiro Fujiwara, Shoshiro Okada   +8 more
doaj   +1 more source

Mechanisms of Regulation of Oligodendrocyte Development by p38 Mitogen-Activated Protein Kinase [PDF]

The Journal of Neuroscience, 2010
Many extracellular and intrinsic factors regulate oligodendrocyte development, but their signaling pathways remain poorly understood. Although the p38 mitogen-activated protein kinase (MAPK)-dependent pathway is implicated in oligodendrocyte progenitor cell (OPC) lineage progression, its molecular targets involved in myelinogenesis are mostly ...
Li-Jin, Chew, William, Coley, Ying, Cheng, Vittorio, Gallo   +3 more
openaire   +2 more sources

Interleukin-8 Secretion from Mycobacterium tuberculosis -Infected Monocytes Is Regulated by Protein Tyrosine Kinases but Not by ERK1/2 or p38 Mitogen-Activated Protein Kinases

, 2002
Mycobacterium tuberculosis upregulates NF-κB binding and interleukin-8 (IL-8) gene expression and secretion in primary human monocytes.
Clara Ameixa, Jon S. Friedland
core   +1 more source

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Remenyi, A, Attila Reményi, Glatz, G, Alexa, A, Glatz, Gábor, Gábor Glatz, Gogl, G, Alexa, Anita, Gógl, Gergő, Anita Alexa, Reményi, Attila, Gergő Gógl, Gógl, Gergo (author), Glatz, Gábor (author), Alexa, Anita (author), Reményi, Attila (author)   +15 more
core   +1 more source

The role of stress-activated protein kinase signaling in renal pathophysiology

Brazilian Journal of Medical and Biological Research, 2009
Two major stress-activated protein kinases are the p38 mitogen-activated protein kinase (MAPK) and the c-Jun amino terminal kinase (JNK). p38 and JNK are widely expressed in different cell types in various tissues and can be activated by a diverse range ...
F.Y. Ma, J. Liu, D.J. Nikolic-Paterson
doaj  

Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock. [PDF]

PLoS ONE, 2015
Some properties of signaling systems, like ultrasensitivity, hysteresis (a form of biochemical memory), and all-or-none responses at a single cell level, are important to understand the regulation of irreversible processes. Xenopus oocytes are a suitable
Nabil Ben Messaoud, Ilina Katzarova, José M López   +2 more
doaj   +1 more source

Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1β

Neurobiology of Disease, 2010
Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine that is primarily produced by microglia in the brain. IL-1β inhibits N-methyl-d-aspartate (NMDA)-induced outward currents (INMDA-OUT) through IL-1 type I receptor (IL-1RI) in hippocampal CA1 ...
Ruoyu Zhang, Li Sun, Yoshinori Hayashi, Xia Liu, Susumu Koyama, Zhou Wu, Hiroshi Nakanishi   +6 more
doaj   +1 more source

Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase [PDF]

Journal of Biological Chemistry, 1997
The p38 mitogen-activated protein kinases (MAPK) are activated by cellular stresses and play an important role in regulating gene expression. We have isolated a cDNA encoding a novel protein kinase that has significant homology (57% amino acid identity) to human p38alpha/CSBP.
X S, Wang, K, Diener, C L, Manthey, S, Wang, B, Rosenzweig, J, Bray, J, Delaney, C N, Cole, P Y, Chan-Hui, N, Mantlo, H S, Lichenstein, M, Zukowski, Z, Yao   +12 more
openaire   +2 more sources

The p38 Mitogen-Activated Protein Kinase Is Involved in Associative Learning in Rabbits [PDF]

The Journal of Neuroscience, 2001
This study examined the role of the mitogen-activated protein kinase (MAPK) family during acquisition of the rabbit's classically conditioned eye-blink response. Eye-blink conditioning produced a significant, bilateral activation of both extracellular signal-regulated protein kinases (ERKs) and p38 MAPK in the anterior cerebellar vermis. There was also
X, Zhen, W, Du, A G, Romano, E, Friedman, J A, Harvey   +4 more
openaire   +2 more sources

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

, 2008
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism.
Dickens, Martin, Davis, Roger J., Gupta, Shashi, Han, Jiahuai, Ulevitch, Richard J., Raingeaud, Joel, Rogers, Jeffrey Scott   +6 more
core   +2 more sources