Results 61 to 70 of about 58,168 (261)

Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock. [PDF]

PLoS ONE, 2015
Some properties of signaling systems, like ultrasensitivity, hysteresis (a form of biochemical memory), and all-or-none responses at a single cell level, are important to understand the regulation of irreversible processes. Xenopus oocytes are a suitable
Nabil Ben Messaoud, Ilina Katzarova, José M López   +2 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1β

Neurobiology of Disease, 2010
Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine that is primarily produced by microglia in the brain. IL-1β inhibits N-methyl-d-aspartate (NMDA)-induced outward currents (INMDA-OUT) through IL-1 type I receptor (IL-1RI) in hippocampal CA1 ...
Ruoyu Zhang, Li Sun, Yoshinori Hayashi, Xia Liu, Susumu Koyama, Zhou Wu, Hiroshi Nakanishi   +6 more
doaj   +1 more source

Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase [PDF]

Journal of Biological Chemistry, 1997
The p38 mitogen-activated protein kinases (MAPK) are activated by cellular stresses and play an important role in regulating gene expression. We have isolated a cDNA encoding a novel protein kinase that has significant homology (57% amino acid identity) to human p38alpha/CSBP.
X S, Wang, K, Diener, C L, Manthey, S, Wang, B, Rosenzweig, J, Bray, J, Delaney, C N, Cole, P Y, Chan-Hui, N, Mantlo, H S, Lichenstein, M, Zukowski, Z, Yao   +12 more
openaire   +2 more sources

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation

Journal of Ginseng Research, 2015
Background: Korean Red Ginseng has been used as a traditional oriental medicine to treat illness and to promote health for several thousand years in Eastern Asia. It is widely accepted that ginseng saponins, ginsenosides, are the major active ingredients
Bo Ra Jeon, Su Jung Kim, Seung Bok Hong, Hwa-Jin Park, Jae Youl Cho, Man Hee Rhee   +5 more
doaj   +1 more source

The p38 Mitogen-Activated Protein Kinase Is Involved in Associative Learning in Rabbits [PDF]

The Journal of Neuroscience, 2001
This study examined the role of the mitogen-activated protein kinase (MAPK) family during acquisition of the rabbit's classically conditioned eye-blink response. Eye-blink conditioning produced a significant, bilateral activation of both extracellular signal-regulated protein kinases (ERKs) and p38 MAPK in the anterior cerebellar vermis. There was also
X, Zhen, W, Du, A G, Romano, E, Friedman, J A, Harvey   +4 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

Toxins, 2016
Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2.
Dakshina M. Jandhyala, John Wong, Nicholas J. Mantis, Bruce E. Magun, John M. Leong, Cheleste M. Thorpe   +5 more
doaj   +1 more source