Results 121 to 130 of about 90,894 (265)

Substrate specificity of mitochondrial intermediate peptidase analysed by a support‐bound peptide library

FEBS Open Bio, 2015
The substrate specificity of recombinant human mitochondrial intermediate peptidase (hMIP) using a synthetic support‐bound FRET peptide library is presented.
M.F.M. Marcondes, F.M. Alves, D.M. Assis, I.Y. Hirata, L. Juliano, V. Oliveira, M.A. Juliano   +6 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Synthetic Peptides as Potential Antigens for Cutaneous Leishmaniosis Diagnosis

Journal of Immunology Research, 2017
This work’s goal was to research new candidate antigens for cutaneous leishmaniosis (CL). In order to reach the goal, we used random peptide phage display libraries screened using antibodies from Leishmania braziliensis patients.
Juliana Seger Link, Silvana Maria Alban, Carlos Ricardo Soccol, Gilberto Vinicius Melo Pereira, Vanete Thomaz Soccol   +4 more
doaj   +1 more source

P3‐184: ALTERED LEVELS OF P3‐ALCβ PEPTIDES IN THE CSF OF AGED MONKEYS AND ALZHEIMER'S DISEASE PATIENTS [PDF]

Alzheimer's & Dementia, 2019
Saori Hata, Ayano Kimura, Haruka Saito, Masaaki Waragai, Takeshi Ikeuchi, Ralph N. Martins, Nobuyuki Kimura, Masaki Nishimura, Toshiharu Suzuki   +8 more
openaire   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM [PDF]

, 2000
The caspase family of cysteine proteases plays important roles in bringing about apoptotic cell death. All caspases studied to date cleave substrates COOH-terminal to an aspartate.
Hawkins, Christine J., Hay, Bruce A., Peterson, Erin P., Vernooy, Stephanie Y., Wang, Susan L., Yoo, Soon Ji   +5 more
core  

Quantitative and functional post-translational modification proteomics reveals that TREPH1 plays a role in plant thigmomorphogenesis

, 2018
Plants can sense both intracellular and extracellular mechanical forces and can respond through morphological changes. The signaling components responsible for mechanotransduction of the touch response are largely unknown.
Braam, Janet, Chehab, E. Wassim, Dai, Chen, Li, Ning, Liu, Jun, Liu, Shichang, Qing, Dongjin, Ren, Feng, Wang, Kai, Wu, Madeline, Yang, Zhu, Zhang, Weiping, Zheng, Qingsong   +12 more
core   +2 more sources

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring [PDF]

, 2002
Surface proteins of Staphylococcus aureus are anchored to the cell wall peptidoglycan by a mechanism requiring a C-terminal sorting signal with an LPXTG motif.
Mazmanian, Sarkis K., Perry, Adrienne M., Schneewind, Olaf, Ton-That, Hung   +3 more
core  

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source