Results 101 to 110 of about 90,894 (265)

Engineering of L-Plastin Peptide-Loaded Biodegradable Nanoparticles for Sustained Delivery and Suppression of Osteoclast Function In Vitro

International Journal of Cell Biology, 2019
We have recently demonstrated that a small molecular weight amino-terminal peptide of L-plastin (10 amino acids; “MARGSVSDEE”) suppressed the phosphorylation of endogenous L-plastin.
Sunipa Majumdar, Aniket S. Wadajkar, Hanan Aljohani, Mark A. Reynolds, Anthony J. Kim, Meenakshi Chellaiah   +5 more
doaj   +1 more source

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy [PDF]

, 2013
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer ...
Chan, Kiat-Hwa, Gopalan, Began, Hauser, Charlotte A. E., Joshi, Mangesh, Lakshmanan, Anupama, Lam, Dang Hoang, Mishra, Archana, Reithofer, Michael R., Wang, Shu   +8 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Application of synthetic peptides in development of a serologic method for laboratory diagnosis of schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 2006
The immunoreactivity of seven peptides synthesized from Schistosoma mansoni proteins, was evaluated by dot-blot and ELISA assays using two different sensitization methodologies.
Edward José de Oliveira, Hermínia Yohko Kanamura, Kioko Takei, Rosario Dominguez Crespo Hirata, Nga Yen Nguyen, Mário Hiroyuki Hirata   +5 more
doaj   +1 more source

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]

, 2008
BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Bates, Declan, Heslop-Harrison, Pat, Kotov, Nikolay, Postlethwaite, Ian, Valeyev, Najil   +4 more
core   +5 more sources

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

SNAC-tag for sequence-specific chemical protein cleavage. [PDF]

, 2019
Site-specific protein cleavage is essential for many protein-production protocols and typically requires proteases. We report the development of a chemical protein-cleavage method that is achieved through the use of a sequence-specific nickel-assisted ...
Dang, Bobo, DeGrado, William F, Hu, Hailin, Mensa, Bruk, Mravic, Marco, Schmidt, Nathan   +5 more
core  

Harnessing Random Polymers as Chemoselective Catalysts With Structural Adaptability: Epoxidation of Olefinic Quaternary Ammonium Salts via Charge Recognition

Chemistry – A European Journal, EarlyView.
The development of chemoselective catalysts that operate across structurally diverse substrates remains a long‐standing challenge. Here, we demonstrate that a random heteropolymer bearing carboxylic acid and urea residues functions as a general epoxidation catalyst for olefinic quaternary ammonium salts.
Yusei Fujii, Kiyosei Takasu, Yusuke Kuroda   +2 more
wiley   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Two‐Pronged Attack: Dual Activation of Fat Reduction Using Near‐Infrared‐Responsive Nanosandwich for Targeted Anti‐Obesity Treatment

Advanced Science
Excessive fat accumulation and chronic inflammation are two typical characteristics of obesity. AMP‐activated protein kinase (AMPK), a master regulator of energy metabolism, is involved in adipogenesis, lipogenesis, and inflammation modulation in adipose
Qiaqia Xiao, Lu Tang, Siying Chen, Yijun Mei, Chuying Wang, Jing Yang, Jing Shang, Shengliang Li, Wei Wang   +8 more
doaj   +1 more source